Journal of Organic Chemistry p. 7621 - 7627 (2017)
Update date:2022-07-30
Topics:
Huang, Yubing
Yu, Yue
Zhu, Zhongzhi
Zhu, Chuanle
Cen, Jinghe
Li, Xianwei
Wu, Wanqing
Jiang, Huanfeng
A novel protocol for the synthesis of α-aryl nitriles has been successfully achieved via a copper-catalyzed cyanation of N-tosylhydrazones employing thiocyanate as the source of cyanide. The features of this method include a convenient operation, readily available substrates, low-toxicity thiocyanate salts, and a broad substrate scope.
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