COMMUNICATIONS
Sodium Iodide-Catalyzed Direct a-Alkoxylation of Ketones with Alcohols
0.3 mmol, 1.5 equiv.), m-CPBA (103.5 mg, 85%, 0.5 mmol,
2.5 equiv.). The tube was fitted with a rubber septum after
using a Schlenk line to evacuate the air and fill the tube
with nitrogen. CH3CN (2.0 mL), methanol (0.5 mL), and
propiophenone (0.2 mmol) were added in turn to the
Schlenk tube through the rubber septum using syringes, and
then the septum was replaced with a Teflon screwcap under
a nitrogen flow. The reaction mixture was stirred at 808C
for 24 h. After cooling down, the reaction mixture was dilut-
ed with 10 mL of diethyl ether, filtered through a pad of
silica gel, followed by washing the pad of the silica gel with
the same solvent (40 mL). The filtrate was extracted three
times with 30 mL of water. The organic phase was dried
over Na2SO4, filtered, concentrated under reduced pressure
(some alcohols with high boiling point should be subjected
to high vacuum). The residue was then purified by flash
chromatography on silica gel to provide the corresponding
product.
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Acknowledgements
Financial support from the 973 Program (2011CB932404,
2011CBA00501) and NSFC (21332001, 21431008 and
21301173) is greatly appreciated.
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Adv. Synth. Catal. 0000, 000, 0 – 0
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