Green Chemistry
Page 8 of 10
DOI: 10.1039/C7GC01593C
Scheme 3 a) Reaction in D2O; b) Proposed mechanism for reduction.
Conclusions
In conclusion, a highly efficient method for the reduction of aryl(heteroaryl)azides and aryl
suphonyl azides to corresponding amines and sulphonamides employing D-glucose as the
hydrogen source along with KOH in water is reported for the first time. The reagents are
inexpensive, non-stinking and non-toxic. The protocol is highly chemoselective and challenging
functional groups such as CN, NO2, COR, and SO2NH2 are well tolerated. The reaction is a rapid
and practical way of accessing amines from aryl, heteroaryl, and suphonyl azides under metal-free
conditions. The present method compares favorably to most of the earlier literature reported
procedures.
Acknowledgments
Dr. N. C. thanks DST for SERB-National Post-Doctoral Fellowship. The authors thank DST-FIST
for funding the ESI-HRMS facility at IIT Delhi.
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