Organic Letters
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The substrate scope is wide, and good yields are obtained even
on a gram scale. Practically, a one-pot, two-step process
involving in situ oxidation of quinoline followed by reductive
olefination has been developed.
ASSOCIATED CONTENT
* Supporting Information
■
S
The Supporting Information is available free of charge on the
Experimental procedures, characterizations, and NMR
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Sauerberg, P. U.S. Patent Appl. US 20030109560 A1, 2003.
(12) Fakhfakh, M. A.; Fournet, A.; Prina, E.; Mouscadet, J.-F.;
AUTHOR INFORMATION
Corresponding Authors
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Franck, X.; Hocquemiller, R.; Figader
11, 5013.
̀
e, B. Bioorg. Med. Chem. 2003,
(13) Alcohol 8aa was prepared in a large amount according to the
following ref: Jin, J.-J.; Niu, H.-Y.; Qu, G.-R.; Guo, H.-M.; Fossey, J. S.
RSC Adv. 2012, 2, 5968.
(14) Although we failed to detect this intermediate in the current
reaction, similar compounds were isolated from the reaction of
quinoline N-oxide and some alkenes. For details, see: (a) Hisano, T.;
Harano, K.; Matsuoka, T.; Suzuki, T.; Murayama, Y. Chem. Pharm.
Bull. 1990, 38, 605. (b) Loska, R.; Mąkosza, M. Mendeleev Commun.
2006, 16, 161.
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
■
We thank the National Natural Science Foundation of China
(Grant No. 21402244), Foundation for the Author of National
Excellent Doctoral Dissertation of P. R. China (Grant No.
201425), the “Start-up Funding from Sun Yat-Sen University”,
and the “One Thousand Youth Talents Plan” for financial
support. We thank Hui Liu (Sun Yat-Sen University) and Teng
Li (Sun Yat-Sen University) for their valuable suggestions
during preparation of this manuscript.
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