Tetrahedron Letters p. 1203 - 1206 (1998)
Update date:2022-08-11
Topics:
Kagoshima, Hirotaka
Hashimoto, Yukihiko
Oguro, Dai
Kutsuna, Takaaki
Saigo, Kazuhiko
The Ph3P/GeCl4 combination was found to be effective for the reduction of various α-bromo carboxylic acid derivatives. When a-bromo carboxylic acid derivatives were treated with Ph3P/GeCl4, the corresponding dehalogenated products were obtained in good to excellent yields. Moreover, selected carboxylic acid derivatives were dehalogenated even when a catalytic amount (0.2 equiv) of GeCl4 was employed in the presence of water (1.0 equiv). The present reduction was also applied to the selective half-reduction of an α,α-dibromo-β-lactam.
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