Journal of labelled compounds and radiopharmaceuticals p. 1041 - 1047 (2005)
Update date:2022-08-16
Topics:
Zhang, Huiping
Bonacorsi Jr., Samuel J.
Chen, Bang-Chi
Leith, Leslie W.
Rinehart, J. Kent
Balasubramanian, Balu
Barrish, Joel C.
A facile and efficient synthesis of d3-labelled Reyataz is described. The key step of synthesis involved the coupling of N-(d 3-methoxycarbonyl)-L-tert-leucine 2b with an advanced chiral non-racemic building block 4. The latter was synthesized in 4 steps from the readily accessible hydrazine derivative 8. Copyright
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