Inorganic Chemistry
Communication
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The various species generated from PCPN display absorbance
and 1H NMR features that are in good agreement with those of
previously reported heme model complexes. This work opens
potential avenues utilizing PCPNs and their inherent tunability
to explore how various protein microenvironments (hydro-
phobic, hydrophilic, hydrogen-bonding-rich, etc.) affect heme
spectroscopic attributes and heme iron reactivity toward relevant
biological ligands (O2, HS−, etc.).
ASSOCIATED CONTENT
* Supporting Information
■
S
The Supporting Information is available free of charge on the
Materials and instrumentation, experimental procedures,
NMR spectra, SEC traces, absorbance spectra, and
AUTHOR INFORMATION
Corresponding Authors
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(14) Collman, J. P.; Fu, L. Synthetic Models for Hemoglobin and
Notes
Myoglobin. Acc. Chem. Res. 1999, 32 (6), 455−463.
(15) Collman, J. P. Functional Analogs of Heme Protein Active Sites.
Inorg. Chem. 1997, 36 (23), 5145−5155.
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
(16) Hartle, M. D.; Prell, J. S.; Pluth, M. D. Spectroscopic
investigations into the binding of hydrogen sulfide to synthetic picket-
fence porphyrins. Dalton Trans. 2016, 45 (11), 4843−4853.
(17) Wang, J. H. Synthetic biochemical models. Acc. Chem. Res. 1970, 3
(3), 90−97.
(18) Twyman, L. J.; Ge, Y. Porphyrin cored hyperbranched polymers
as heme protein models. Chem. Commun. 2006, No. 15, 1658−1660.
(19) Weyermann, P.; Diederich, F. Dendritic Iron Porphyrins with a
Tethered Axial Ligand as New Model Compounds for Heme
Monooxygenases. Helv. Chim. Acta 2002, 85 (2), 599−617.
(20) Caminade, A.-M.; Yan, D.; Smith, D. K. Dendrimers and
hyperbranched polymers. Chem. Soc. Rev. 2015, 44 (12), 3870−3873.
(21) Hanlon, A. M.; Lyon, C. K.; Berda, E. B. What Is Next in Single-
Chain Nanoparticles? Macromolecules 2016, 49 (1), 2−14.
(22) Lyon, C. K.; Prasher, A.; Hanlon, A. M.; Tuten, B. T.; Tooley, C.
A.; Frank, P. G.; Berda, E. B. A brief user’s guide to single-chain
nanoparticles. Polym. Chem. 2015, 6 (2), 181−197.
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Data were collected on the 400 and 500 MHz NMR within the
University Instrumentation Center at the University of New
Hampshire in Durham, NH. S.P. and E.B.B. graciously
acknowledge financial support from the University of New
Hampshire. E.B.B. additionally acknowledges the Army Research
Office for support through Award W911NF-14-1-0177 and the
NIST for support through Award 70NANB15H060. Finally, the
authors thank Alex Vorrilas for designing the Table of Contents
graphic.
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