Beilstein J. Org. Chem. 2014, 10, 641–652.
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Supporting Information File 4
11.Ley, S. V.; Ingham, R. J.; O’Brien, M.; Browne, D. L.
12.Yeates, S. What Is Version Control? Why Is It Important For Due
Dec 19, 2013).
Control sequence for performing DoE experiments using
intermediate from a reservoir. Alternate web version:
Raspberry Pi is a trademark of the Raspberry Pi Foundation.
14.Morley, A. D.; Pugliese, A.; Birchall, K.; Bower, J.; Brennan, P.;
Brown, N.; Chapman, T.; Drysdale, M.; Gilbert, I. H.; Hoelder, S.;
Jordan, A.; Ley, S. V.; Merritt, A.; Miller, D.; Swarbrick, M. E.;
Wyatt, P. G. Drug Discovery Today 2013, 18, 1221–1227.
Supporting Information File 5
Flow chart representation of the control sequence for
performing DoE experiments using intermediate from a
reservoir.
15.Dougherty, D. Curr. Opin. Chem. Biol. 2000, 4, 645–652.
16.Battilocchio, C.; Baxendale, I. R.; Biava, M.; Kitching, M. O.; Ley, S. V.
17.Eichhorn, E.; Roduit, J.-P.; Shaw, N.; Heinzmann, K.; Kiener, A.
Tetrahedron: Asymmetry 1997, 8, 2533–2536.
Supporting Information File 6
Control sequence for performing two-step hydrogenation
process with control and monitoring. Alternate web
version:
18.Piperazine-2-carboxamide listed by Fluorochem (P/N 068934) at
£240/1g on 6th Jan 2013.
19.García-Álvarez, R.; Crochet, P.; Cadierno, V. Green Chem. 2013, 15,
20.Dugger, R. W.; Ragan, J. A.; Brown Ripin, D. H.
21.Battilocchio, C.; Hawkins, J. M.; Ley, S. V. Org. Lett. 2014, 16,
22.Battilocchio, C.; Hawkins, J. M.; Ley, S. V. Org. Lett. 2013, 15,
Acknowledgements
23.Chorghade, R.; Battilocchio, C.; Hawkins, J. M.; Ley, S. V. Org. Lett.
We gratefully acknowledge Pfizer Worldwide Research and
Development (C.B. and J.M.H.), the Ralph Raphael studentship
(R.J.I.) and the BP endowment (S.V.L.) for financial support.
We also thank Dr. Emiliana Dvininov (MEL Chemicals,
Manchester) for the gift of the zirconia catalyst.
24.Tamura, M.; Wakasugi, H.; Shimizu, K.; Satsuma, A. Chem.–Eur. J.
25.Zirconium hydroxide was generously donated by MEL Chemicals (cod.
XZO631/01); the surface area of the catalyst was measured by the
BET method and was found to be 370 square metres per gram.
26.Ingham, R. J. Octopus, version 0.1, 2014.
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