4-BENZYL-1(2H)-PHTHALAZINONE

Base Information

• Chemical Name: 4-BENZYL-1(2H)-PHTHALAZINONE
• CAS No.: 32003-14-8
• Molecular Formula: C15H12N2O
• Molecular Weight: 236.273
• Hs Code.: 2933990090
• Mol file: 32003-14-8.mol

Synonyms:4-Benzyl-1(2H)-phthalazinone;phthalazinone,1;4-benzylphthalaz-1-one;benzylphthalazinone;4-benzyl-phthalazin-1-one;4-benzylphthalazin-1(2H)-one;1,2-dihydro-4-benzyl-1-phthalazinone;4-Benzyl-1-phthalazinone;

Chemical Property of 4-BENZYL-1(2H)-PHTHALAZINONE

Chemical Property:

• PSA: 45.75000
• LogP: 2.51390
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

4-Benzyl-1(2H)-phthalazinone >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-BENZYL-1(2H)-PHTHALAZINONE

There total 34 articles about 4-BENZYL-1(2H)-PHTHALAZINONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(Z)-3-benzylidenephthalide (4767-56-0) → 4-benzyl-2H-phthalazin-1-one (32003-14-8)

Guidance literature:

With hydrazine; In tetrahydrofuran; at 20 - 60 ℃; for 6h; Sealed tube;

DOI:10.1016/j.tetlet.2014.12.121

Reference yield: 95.0%

(Z)-3-benzylidene-2-(quinolin-8-yl)isoindolin-1-one (1610881-75-8) → 4-benzyl-2H-phthalazin-1-one (32003-14-8)

Guidance literature:

With hydrazine hydrate; sodium hydroxide; In ethanol; at 120 ℃; for 1h; Microwave irradiation;

DOI:10.3762/bjoc.11.177

Reference yield: 93.0%

phenylacetic acid (103-82-2) + phthalic anhydride (85-44-9) → 4-benzylphthalazin-1-ol (32003-14-8)

Guidance literature:

With hydrazine hydrate; In ethanol; at 30 ℃; Sonication;

DOI:10.1002/jhet.3622

upstream raw materials:

(Z)-3-benzylidenephthalide

N-aminophthalamide

benzylmagnesium chloride

2-amino-3-benzylideneisoindolin-1-one

Downstream raw materials:

4-benzyl-1-oxo-2-<1(2H)phthalazonyl>methyl-p-aminophenylacetic acid

4-Benzyl-2-phenylaminomethyl-2H-phthalazin-1-one

4-[(4-Benzyl-1-oxo-1H-phthalazin-2-ylmethyl)-amino]-benzoic acid ethyl ester

4-benzyl-2-(2'-cyanoethyl)phthalazin-1(2H)-one

Refernces

• 1、 Munín, Javier,Santana, Lourdes,Uriarte, Eugenio,Borges, Fernanda,Quezada, Elías. "A comparative synthesis of 6-benzyl-2,3-dihydroimidazo[2,1-a]phthalazine and 2H-7-benzyl-3,4-dihydropyrimido[2,1-a]phthalazine". . p. 828 - 830. Retrieved 2015.
• 2、 Lee, Wan-Chen Cindy,Wang, Wei,Li, Jie Jack. "Copper(II)-Mediated ortho-Selective C(sp2)-H Tandem Alkynylation/Annulation and ortho-Hydroxylation of Anilides with 2-Aminophenyl-1H-pyrazole as a Directing Group". supporting information. p. 2382 - 2388. Retrieved 2018/02/23.