(5-broMo-2-chloro-phenyl)-(4-ethoxy-phenyl)-Methanone

Base Information

• Chemical Name: (5-broMo-2-chloro-phenyl)-(4-ethoxy-phenyl)-Methanone
• CAS No.: 333361-49-2
• Molecular Formula: C14H10BrClO2
• Molecular Weight: 325.589
• Hs Code.: 2914700090
• Mol file: 333361-49-2.mol

Synonyms:(5-Bromo-2-chlorophenyl)(4-methoxyphenyl)methanone;

Chemical Property of (5-broMo-2-chloro-phenyl)-(4-ethoxy-phenyl)-Methanone

Chemical Property:

• PSA: 26.30000
• LogP: 4.34210
• Storage Temp.: 2-8°C
• Solubility.: Dichloromethane; Ethyl Acetate

Purity/Quality:

98%,99%, ^*data from raw suppliers

(5-Bromo-2-chlorophenyl)(4-methoxyphenyl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (5-Bromo-2-chlorophenyl)(4-methoxyphenyl)methanone is an intermediate in synthesizing Dapagliflozin-D5 (D185372), a labelled analogue of Dapagliflozin (D185370), which is a selective sodium-glucose cotransporter-2 inhibitor that reduces renal glucose reabsorption and is used to treat patients with type 2 diabetes.

Technology Process of (5-broMo-2-chloro-phenyl)-(4-ethoxy-phenyl)-Methanone

There total 6 articles about (5-broMo-2-chloro-phenyl)-(4-ethoxy-phenyl)-Methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.3%

5-bromo-2-chloro-benzoyl chloride (21900-52-7) + methoxybenzene (100-66-3) → (5-bromo-2-chlorophenyl)(4-methoxyphenyl)methanone (333361-49-2)

Guidance literature:

methoxybenzene; With indium(III) chloride; iron(III) chloride; In dichloromethane; at -5 ℃; for 0.5h;

5-bromo-2-chloro-benzoyl chloride; In dichloromethane; at 0 - 10 ℃; for 1h; Reagent/catalyst;

Reference yield: 64.3%

5-bromo-2-chlorobenzoic acid (21739-92-4) + methoxybenzene (100-66-3) → (5-bromo-2-chlorophenyl)(4-methoxyphenyl)methanone (333361-49-2)

Guidance literature:

5-bromo-2-chlorobenzoic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; for 14h;

methoxybenzene; With aluminum (III) chloride; In dichloromethane; at -5 - 5 ℃; for 1h;

With water; In dichloromethane; at 0 ℃;

Reference yield: 64.0%

5-bromo-2-chlorobenzoic acid (21739-92-4) → (5-bromo-2-chlorophenyl)(4-methoxyphenyl)methanone (333361-49-2)

Guidance literature:

5-bromo-2-chlorobenzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 14h;

With aluminum (III) chloride; methoxybenzene; In dichloromethane; at -5 - 5 ℃; for 1h;

upstream raw materials:

methoxybenzene

5-bromo-2-chloro-benzoyl chloride

5-bromo-2-chlorobenzoic acid

Refernces

• 1、 -. "GLUCOPYRANOSE DERIVATIVES USEFUL AS SGLT2 INHIBITORS". Page/Page column 52-53. . Retrieved 2020/06/10.
• 2、 -. "Synthetic method for empagliflozin related substance IMPD". Paragraph 0079; 0081. . Retrieved 2019/07/10.