2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide hydrochloride

Base Information

• Chemical Name: 2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide hydrochloride
• CAS No.: 344458-15-7
• Molecular Formula: C17H17N3O2.ClH
• Molecular Weight: 316.78200
• Hs Code.: 2933990090
• UNII: VHK9YBZ6SB
• ChEMBL ID: CHEMBL3233481
• DSSTox Substance ID: DTXSID30587910
• Mol file: 344458-15-7.mol

Synonyms:344458-15-7;PJ34 hydrochloride;PJ34 HCl;2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide hydrochloride;PJ 34 Hydrochloride;PARP Inhibitor VIII, PJ34;PJ-34 HCl;PJ-34 hydrochloride;PJ34 (hydrochloride);PJ 34 HCl;VHK9YBZ6SB;N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide Hydrochloride;344458-15-7 (HCl);1-(Dimethylamino)-3-(6-hydroxyphenanthridin-2-yl)propan-2-one hydrochloride;2-(Dimethylamino)-N-(6-hydroxyphenanthridin-2-yl)acetamide hydrochloride;Acetamide, N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)-, hydrochloride (1:1);N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-(N,N-dimethylamino)acetamide hydrochloride;PJ34hydrochloride;RURAZZMDMNRXMI-UHFFFAOYSA-N;PJ34 monohydrochloride;UNII-VHK9YBZ6SB;2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide;hydrochloride;C17H17N3O2.HCl;SCHEMBL5074001;CHEMBL3233481;DTXSID30587910;EX-A251;CHEBI:167904;BCP02366;HB1474;MFCD16618379;s7300;AKOS016012781;CCG-267823;CS-1462;AC-32739;AS-72775;HY-13688;SW219891-1;A874967;J-019612;2-(dimethylamino)-n-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide hcl;2-(DIMETHYLAMINO)-N-(6-OXO-5H-PHENANTHRIDIN-2-YL)ACETAMIDE HYDROCHLORIDE;N(2),N(2)-dimethyl-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)glycinamide hydrochloride;N(2),N(2)-dimethyl-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)glycinamide--hydrogen chloride;N,N-dimethyl-2-oxo-2-[(6-oxo-5,6-dihydrophenanthridin-2-yl)amino]ethan-1-aminium chloride;N,N-dimethyl-2-oxo-2-[(6-oxo-5,6-dihydrophenanthridin-2-yl)amino]ethanaminium chloride;n-(6-oxo-5,6-dihydro-phenanthridin-2-yl)-n,n-dimethylacetamide hydrochloride;2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide hydrochloride;N~2~,N~2~-Dimethyl-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)glycinamide--hydrogen chloride (1/1)

Chemical Property of 2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide hydrochloride

Chemical Property:

• Vapor Pressure: 1.87E-12mmHg at 25°C
• Boiling Point: 539.1oC at 760 mmHg
• Flash Point: 279.9oC
• PSA: 53.17000
• LogP: 3.11400
• Storage Temp.: Desiccate at RT
• Sensitive.: Light Sensitive & Hygroscopic
• Solubility.: H2O: soluble22mg/mL
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 331.1087545
• Heavy Atom Count: 23
• Complexity: 438

Purity/Quality:

98%,99%, ^*data from raw suppliers

PJ 34 hydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32.Cl
• Description: PJ-34 HCl (344458-15-7) is a potent and selective inhibitor of PARP1 and 2. EC50 = 20 nM.1?Reduces ischemia reperfusion injury in a mouse model.2 Displays anti-inflammatory effects in a transient focal cerebral ischemia mouse model.3 PJ-34 HCl causes PARP1 independent, p21 dependent mitotic arrest.4
• Uses: A poly adenosine diphosphate-ribose polymerase inhibitor, attenuates chromate-induced nephrotoxicity. east cancer MCF-7. A poly adenosine diphosphate-ribose polymerase inhibitor, attenuates chromate-induced nephrotoxicity. PJ-34 has a lethal effect on breast cancer cells, both in vitro and in vivo, in particular on breast cancer MCF-7. PJ-34 hydrochloride hydrate has been used:as a poly(ADP-ribose) polymerase (PARP) inhibitor 1 in rats to test the effect of PAPR1 in neuropathic pain as a component of protein extraction buffer to enable visualization of the high-molecular-weight smear of PARylated proteins in various cell samples as PARP inhibitor in murine MLE-12 epithelial cell line