4,4-Difluoro-N-((1S)-3-oxo-1-phenylpropyl)cyclohexane-1-carboxamide

Base Information Edit

Chemical Name:4,4-Difluoro-N-((1S)-3-oxo-1-phenylpropyl)cyclohexane-1-carboxamide
CAS No.:376348-78-6
Molecular Formula:C16H19F2NO2
Molecular Weight:295.329
Hs Code.:2924299090
European Community (EC) Number:638-777-9,920-127-3
UNII:SA287A977G
DSSTox Substance ID:DTXSID60958679
Mol file:376348-78-6.mol

Synonyms:376348-78-6;4,4-DIFLUORO-N-((1S)-3-OXO-1-PHENYLPROPYL)CYCLOHEXANE-1-CARBOXAMIDE;(S)-4,4-Difluoro-N-(3-oxo-1-phenylpropyl)cyclohexanecarboxamide;EC 638-777-9;4,4-Difluoro-N-((1S)-3-oxo-1-phenylpropyl)cyclohexanecarboxamide;4,4-DIFLUORO-N-[(1S)-3-OXO-1-PHENYLPROPYL]CYCLOHEXANE-1-CARBOXAMIDE;(S)-4,4-difluoro-N-(3-oxo-1-phenylpropyl)cyclohexane-1-carboxamide;4,4-difluoro-n-[(1S)-3-oxo-1-phenylpropyl]cyclohexanecarboxamide;Cyclohexanecarboxamide, 4,4-difluoro-N-[(1S)-3-oxo-1-phenylpropyl]-;SCHEMBL709191;DTXSID60958679;SA287A977G;AMY14866;4,4-difluoro-cyclohexanecarboxylic acid ((S)-3-oxo-1-phenyl-propyl)-amide;CS-0451827;A857075;4,4-Difluoro-N-(3-oxo-1-phenylpropyl)cyclohexane-1-carboximidic acid

Suppliers and Price of 4,4-Difluoro-N-((1S)-3-oxo-1-phenylpropyl)cyclohexane-1-carboxamide

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Biosynth Carbosynth
4,4-Difluoro-N-((1S)-3-oxo-1-phenylpropyl)cyclohexanecarboxa
1 g
$ 1000.00

Biosynth Carbosynth
4,4-Difluoro-N-((1S)-3-oxo-1-phenylpropyl)cyclohexanecarboxa
500 mg
$ 750.00

Biosynth Carbosynth
4,4-Difluoro-N-((1S)-3-oxo-1-phenylpropyl)cyclohexanecarboxa
250 mg
$ 500.00

Biosynth Carbosynth
4,4-Difluoro-N-((1S)-3-oxo-1-phenylpropyl)cyclohexanecarboxa
100 mg
$ 300.00

Biosynth Carbosynth
4,4-Difluoro-N-((1S)-3-oxo-1-phenylpropyl)cyclohexanecarboxa
50 mg
$ 200.00

Total 15 raw suppliers

Chemical Property of 4,4-Difluoro-N-((1S)-3-oxo-1-phenylpropyl)cyclohexane-1-carboxamide Edit

Chemical Property:

PSA：46.17000
LogP:3.64930
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:295.13838517
Heavy Atom Count:21
Complexity:357

Purity/Quality:

99.9% ^*data from raw suppliers

4,4-Difluoro-N-((1S)-3-oxo-1-phenylpropyl)cyclohexanecarboxa ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(CCC1C(=O)NC(CC=O)C2=CC=CC=C2)(F)F
Isomeric SMILES:C1CC(CCC1C(=O)N[C@@H](CC=O)C2=CC=CC=C2)(F)F
Uses 4,4-Difluoro-N-((1S)-3-oxo-1-phenylpropyl)cyclohexane-1-carboxamide is an organic amide and can be used as a pharmaceutical intermediate. (S)-4,4-Difluoro-N-(3-oxo-1-phenylpropyl)cyclohexanecarboxamide acts as a reagent in the synthesis of CCR5 antagonists which are used in HIV therapy and may also be relevant for the treatment of graft-vs.-host disease and Staphylococcus aureus infection.

Technology Process of 4,4-Difluoro-N-((1S)-3-oxo-1-phenylpropyl)cyclohexane-1-carboxamide

There total 12 articles about 4,4-Difluoro-N-((1S)-3-oxo-1-phenylpropyl)cyclohexane-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 376348-77-5
(S)-4,4-difluoro-N-(3-hydroxy-1-phenylpropyl)cyclohexanecarboxamide

: 376348-78-6
4,4-difluorocyclohexanecarboxylic acid (3-oxo-1-phenyl-propyl)-amide

Guidance literature:: With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium bromide; In water; ethyl acetate; at 0 ℃; for 0.5h; Cooling with ice;