4-Hydroxy-1-naphthaldehyde

Base Information

• Chemical Name: 4-Hydroxy-1-naphthaldehyde
• CAS No.: 7770-45-8
• Molecular Formula: C11H8O2
• Molecular Weight: 172.183
• Hs Code.: 2912499000
• Mol file: 7770-45-8.mol

Synonyms:1-Naphthaldehyde,4-hydroxy- (6CI,7CI,8CI);4-Hydroxy-1-naphthaldehyde;4-Hydroxy-1-naphthalenecarbaldehyde;4-Hydroxy-1-naphthalenecarboxaldehyde;4-Hydroxynaphthalene-1-carboxaldehyde;NSC 401124;

Chemical Property of 4-Hydroxy-1-naphthaldehyde

Chemical Property:

• Appearance/Colour: off-white or brown powder
• Vapor Pressure: 7.75E-06mmHg at 25°C
• Melting Point: 179-182 °C
• Refractive Index: 1.719
• Boiling Point: 364.9 °C at 760 mmHg
• PKA: 6.66±0.40(Predicted)
• Flash Point: 155.7 °C
• PSA: 37.30000
• Density: 1.288 g/cm³
• LogP: 2.35790
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99.5% ^*data from raw suppliers

4-Hydroxy-1-naphthaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 4-Hydroxy-1-naphthaldehyde was used in the preparation of racemic 1- and 2-naphthol analogues of tyrosine, 2-amino-3-(4-hydroxy-1-naphthyl)propanoic acid hydrochloride and 2-amino-3-(6-hydroxy-2-naphthyl)propanoic acid hydrobromide.

Technology Process of 4-Hydroxy-1-naphthaldehyde

There total 24 articles about 4-Hydroxy-1-naphthaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C16H16O5 → 4-hydroxy-1-naphthaldehyde (7770-45-8)

Guidance literature:

C₁₆H₁₆O₅; With iron(III) chloride; chloro-trimethyl-silane; In dichloromethane; at 0 ℃; for 16h;

With water;

DOI:10.3987/COM-18-S(F)50

Reference yield: 93.0%

1-dimethoxymethyl-substituted 1,4-epoxy-1,4-dihydronaphthalene → 4-hydroxy-1-naphthaldehyde (7770-45-8)

Guidance literature:

1-dimethoxymethyl-substituted 1,4-epoxy-1,4-dihydronaphthalene; With ferric(III) bromide; In dichloromethane; at 0 ℃; for 6h;

With water; regioselective reaction;

DOI:10.3987/COM-18-S(F)50

Reference yield: 84.0%

α-naphthol (90-15-3) + Dichloromethyl methyl ether (4885-02-3) → 4-hydroxy-1-naphthaldehyde (7770-45-8)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at -20 - 20 ℃; for 1.08333h; Inert atmosphere;

DOI:10.1016/j.tet.2017.04.028

upstream raw materials:

formaldehyd

α-naphthol

hydrogen cyanide

N-methyl-N-phenylformamide

Downstream raw materials:

4-methyl-1-naphthol

4-benzyloxynaphthalene-1-carbaldehyde

4-((phenylimino)methyl)naphthalen-1-ol

4-methoxy-1-naphthaldehyde

Refernces

• 1、 McLaughlin, Michael F.,Massolo, Elisabetta,Cope, Thomas A.,Johnson, Jeffrey S.. "Phenolic Oxidation Using H2O2 via in Situ Generated para-Quinone Methides for the Preparation of para-Spiroepoxydienones". supporting information. p. 6504 - 6507. Retrieved 2019/09/04.
• 2、 Antien, Kevin,Viault, Guillaume,Pouységu, Laurent,Peixoto, Philippe A.,Quideau, Stéphane. "Asymmetric dearomative spirolactonization of naphthols using λ3-iodanes under chiral phase-transfer catalysis". supporting information. p. 3684 - 3690. Retrieved 2017/06/13.