1,4,5,6-TETRAHYDROPYRIMIDINE

Base Information

• Chemical Name: 1,4,5,6-TETRAHYDROPYRIMIDINE
• CAS No.: 1606-49-1
• Molecular Formula: C4H8N2
• Molecular Weight: 84.1209
• Hs Code.: 2933599090
• Mol file: 1606-49-1.mol

Synonyms:1,4,5,6-Tetrahydropyrimidine;NSC 72087;

Chemical Property of 1,4,5,6-TETRAHYDROPYRIMIDINE

Chemical Property:

• Appearance/Colour: Viscous colorless liquid
• Vapor Pressure: 0.00785mmHg at 25°C
• Melting Point: 88-89 °C
• Refractive Index: n20/D 1.5194(lit.)
• Boiling Point: 268.1 °C at 760 mmHg
• PKA: 12.21±0.20(Predicted)
• Flash Point: 115.9 °C
• PSA: 24.39000
• Density: 1.08 g/cm³
• LogP: -0.22760

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,4,5,6-Tetrahydropyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Derivatives of 1,4,5,6-Tetrahydropyrimidine can act as neuromuscular blocking, cardiovascular and antidepresant agents Derivatives of 1,4,5,6-Tetrahydropyrimidine can act as neuromuscular blocking, cardiovascular and antidepressant agents.

Technology Process of 1,4,5,6-TETRAHYDROPYRIMIDINE

There total 15 articles about 1,4,5,6-TETRAHYDROPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 1,4,5,6-tetrahydropyrimidine (1606-49-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; acetic acid; at 20 ℃; for 15h; under 760.051 Torr;

Reference yield: 90.0%

N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + Trimethylenediamine (109-76-2,54018-94-9) → 1,4,5,6-tetrahydropyrimidine (1606-49-1)

Guidance literature:

at 90 - 110 ℃; for 0.5h;

DOI:10.3987/com-96-7511

Reference yield: 89.0%

1-(3-nitrobenzenesulfonyl)-3,4-dimethylimidazolinium iodide + Trimethylenediamine (109-76-2,54018-94-9) → 1,4,5,6-tetrahydropyrimidine (1606-49-1)

Guidance literature:

In acetonitrile; for 1h; Heating;

DOI:10.3987/COM-05-10528

upstream raw materials:

PYRIMIDINE

1,3,5-Triazine

Trimethylenediamine

2,5-dichloropyrimidine

Downstream raw materials:

2-Chloro-5-[(5,6-dihydro-1(4H)-pyrimidinyl)methyl]-N-(tricyclo[3.3.1.13.7]dec-1-ylmethyl)-benzamide

N-1-[1-(2,6-diisopropylphenylimino)ethyl]-4,5,6-trihydropyrimidine

1-(3-Phenyl-3-cyclohexyl-3-hydroxy)propyl-1,4,5,6-tetrahydropyrimidine hydrochloride

5-(1,4,5,6-tetrahydropyrimidin-1-yl)-3-methyl-2-nitro aniline

Refernces

• 1、 Anderson et al.. "-". . p. 482. Retrieved 1969.
• 2、 -. "PRODUCTION METHOD OF CYCLIC COMPOUND". Paragraph 0057; 0059; 0062-0063. . Retrieved 2021/05/05.
• 3、 Kim, Sangmin,Loose, Florian,Bezdek, Máté J.,Wang, Xiaoping,Chirik, Paul J.. "Hydrogenation of N-Heteroarenes Using Rhodium Precatalysts: Reductive Elimination Leads to Formation of Multimetallic Clusters". . p. 17900 - 17908. Retrieved 2019/11/19.