(S)-(-)-Propranolol hydrochloride

Base Information Edit

Chemical Name:(S)-(-)-Propranolol hydrochloride
CAS No.:4199-10-4
Molecular Formula:C16H21NO2.ClH
Molecular Weight:295.809
Hs Code.:2906199090
European Community (EC) Number:224-096-0
NSC Number:757295
UNII:YP6GDU0L78
DSSTox Substance ID:DTXSID50873367
Wikidata:Q27294637
ChEMBL ID:CHEMBL545328
Mol file:4199-10-4.mol

Synonyms:(S)-(-)-Propranolol hydrochloride;4199-10-4;(S)-Propranolol hydrochloride;Levopropranolol hydrochloride;MFCD00064547;(2s)-1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol hydrochloride;YP6GDU0L78;S(-)-Propranolol hydrochloride;Propranolol hydrochloride, (-)-;(S)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride;EINECS 224-096-0;(S)-(-)-Propranolol (hydrochloride);(2S)-1-(naphthalen-1-yloxy)-3-[(propan-2-yl)amino]propan-2-ol hydrochloride;(2S)-1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol;hydrochloride;(S)-(2-Hydroxy-3-(naphthyloxy)propyl)isopropylammonium chloride;SR-01000076087;l-Propranolol Chlorhydrate;l-Propranolol Hydrochloride;(S)-Propranolol (hydrochloride);(S)-1-(isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol hydrochloride;(S)-Propanolol Hydrochloride;L-(-)-Propranolol Hydrochloride;(S)-(-)-1-((1-METHYLETHYL)AMINO)-3-(1-NAPHTHALENYLOXY)-2-PROPANOL HYDROCHLORIDE;(S)-(-)-1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol hydrochloride;(S)-Propranolol HCl;UNII-YP6GDU0L78;SCHEMBL41689;MLS000859887;SPECTRUM1500514;CHEMBL545328;HY-B0573A;DTXSID50873367;(S)-()-Propranolol hydrochloride;HMS1920L20;Pharmakon1600-01500514;(S)-(-)-PROPRANOLOL HCL;S-(-)-1-Isopropylamino-3-(1-naphthoxy)-2-propanol Hydrochloride;Tox21_501023;(2S)-(-)-Propanolol Hydrochloride;NSC757295;PROPRANOLOL HYDROCHLORIDE, L-;s5981;AKOS015960770;CCG-212772;LP01023;1-ALLYL-35-DIMETHYLPYRAZOLE96;PROPRANOLOL HYDROCHLORIDE, (S)-;NCGC00261708-01;AC-12294;AS-61344;SMR000326749;LS-184130;CS-0019986;EU-0101023;A13428;P 8688;SR-01000597856;SR-01000076087-1;SR-01000076087-5;SR-01000076087-6;SR-01000597856-1;Q27294637;(S)-(-)-Propranolol hydrochloride, >=98% (TLC), powder;(2S)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride (1:1);2-PROPANOL, 1-((1-METHYLETHYL)AMINO)-3-(1-NAPHTHALENYLOXY)-, HYDROCHLORIDE, (S)-;2-PROPANOL, 1-(ISOPROPYLAMINO)-3-(1-NAPHTHYLOXY)-, HYDROCHLORIDE, (-)-;2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, (2S)-, hydrochloride (1:1)

Suppliers and Price of (S)-(-)-Propranolol hydrochloride

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-(?)-Propranolol hydrochloride
10g
$ 1260.00

Tocris
(S)-(?)-Propranolol hydrochloride ≥98%(HPLC)
100
$ 86.00

Sigma-Aldrich
(S)-(?)-Propranolol hydrochloride ≥98% (TLC), powder
100mg
$ 93.10

Sigma-Aldrich
(S)-(?)-Propranolol hydrochloride ≥98% (TLC), powder
500mg
$ 375.00

Medical Isotopes, Inc.
(S)-PropranololHCl
1 g
$ 650.00

ChemScene
(S)-(?)-Propranolol hydrochloride ≥97.0%
100mg
$ 95.00

ChemScene
(S)-(?)-Propranolol hydrochloride ≥97.0%
500mg
$ 277.00

Cayman Chemical
(S)-(-)-Propranolol (hydrochloride) ≥98%
500mg
$ 232.00

Cayman Chemical
(S)-(-)-Propranolol (hydrochloride) ≥98%
250mg
$ 131.00

Cayman Chemical
(S)-(-)-Propranolol (hydrochloride) ≥98%
50mg
$ 29.00

Total 24 raw suppliers

Chemical Property of (S)-(-)-Propranolol hydrochloride Edit

Chemical Property:

Melting Point:193-195 °C(lit.)
Boiling Point:434.9 °C at 760 mmHg
Flash Point:216.8 °C
PSA：41.49000
LogP:3.77040
Storage Temp.:2-8°C
Solubility.:ethanol: 10 mg/mL
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:295.1339066
Heavy Atom Count:20
Complexity:257

Purity/Quality:

98%,99%, ^*data from raw suppliers

(S)-(?)-Propranolol hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 20/21/22
Safety Statements: 36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O.Cl
Isomeric SMILES:CC(C)NC[C@@H](COC1=CC=CC2=CC=CC=C21)O.Cl
Description (S)-(-)-Propranolol is the active enantiomer of propranolol, a β-adrenergic receptor antagonist with log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively. It is also a non-specific serotonin receptor antagonist. Propanolol was one of the first β-adrenergic receptor blockers to be widely used in clinical practice for the treatment of hypertension, angina pectoris, and cardiac ischemia.
Uses active enantiomer, 5-HT1 receptor antagonist The S-enantiomer of Propranolol (P831800). β?Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II). Antihypertensor;Beta-adrenergic blocking agent

Technology Process of (S)-(-)-Propranolol hydrochloride

There total 35 articles about (S)-(-)-Propranolol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 108508-19-6
(R)-(-)-1-chloro-2-acetoxy-3-(1-naphthyloxy)propane

: 75-31-0
isopropylamine

: 4199-10-4
(S)-(-)-propanolol hydrochloride

Guidance literature:: With sodium hydroxide; water; for 16h; Ambient temperature;
DOI:10.1021/jo00018a032

Reference yield: 92.0%

: 16204-21-0
N-isopropyl-3-(naphthyloxy)-2-oxo-1-propylamine hydrochloride

: 4199-10-4
(S)-(-)-propanolol hydrochloride

Guidance literature:: With chloro(1,5-cyclooctadiene)rhodium(I) dimer; hydrogen; triethylamine; (2S,4S)-N-(methylcarbamoyl)-4-(dicyclohexylphosphino)-2-<(diphenylphosphino)methyl>pyrrolidine; In methanol; at 50 ℃; for 20h; under 14710.2 Torr;