2,6-DIMETHYL-5-IODO-4(3H)-PYRIMIDONE

Base Information

• Chemical Name: 2,6-DIMETHYL-5-IODO-4(3H)-PYRIMIDONE
• CAS No.: 83410-37-1
• Molecular Formula: C6H7IN2O
• Molecular Weight: 250.039
• Hs Code.: 2933599090
• Mol file: 83410-37-1.mol

Synonyms:2,6-Dimethyl-5-iodo-4-hydroxypyrimidine;NSC 246041;4(1H)-Pyrimidinone,5-iodo-2,6-dimethyl- (9CI);

Chemical Property of 2,6-DIMETHYL-5-IODO-4(3H)-PYRIMIDONE

Chemical Property:

• Vapor Pressure: 0.0168mmHg at 25°C
• Refractive Index: 1.687
• Boiling Point: 254.9 °C at 760 mmHg
• Flash Point: 107.9 °C
• PSA: 46.01000
• Density: 2.03 g/cm³
• LogP: 1.40360
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98% ^*data from raw suppliers

5-iodo-2,6-dimethylpyrimidin-4-ol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-DIMETHYL-5-IODO-4(3H)-PYRIMIDONE

There total 2 articles about 2,6-DIMETHYL-5-IODO-4(3H)-PYRIMIDONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4-hydroxy 2,6-dimethylpyrimidine (6622-92-0) → 5-iodo-2,6-dimethyl-pyrimidin-4-ol (83410-37-1)

Guidance literature:

With iodine; sodium hydroxide; In water; at 80 ℃; for 2h;

Reference yield: 56.0%

2,6-dimethyl-1H-pyrimidin-4-one (6622-92-0) → 5-Iodo-2,6-dimethyl-4(3H)-pyrimidinone (83410-37-1)

Guidance literature:

With iodine; chlorine; In acetic acid; 1.) room temp., 30 min, 2.) 60 deg C, 3 h;

DOI:10.1055/s-1984-30796

Reference yield: 92.0%

4-methoxyphenylacetylen (768-60-5) + 5-iodo-2,6-dimethyl-pyrimidin-4-ol (83410-37-1) → 5-(2-(4-methoxyphenyl)ethynyl)-2,6-dimethylpyrimidin-4-ol (929880-39-7)

Guidance literature:

With copper(l) iodide; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; for 24h;

DOI:10.1016/j.tet.2006.12.077

upstream raw materials:

2,6-dimethyl-1H-pyrimidin-4-one

4-hydroxy 2,6-dimethylpyrimidine

Downstream raw materials:

2,6-dimethyl-5-styryl-4(3H)-pyrimidinone

4-chloro-5-iodo-2,6-dimethylpyrimidine

2,4-dimethyl-6-phenylfuro<2,3-d>pyrimidine

2,6-dimethyl-5-phenylethynyl-4(3H)-pyrimidinone

Refernces

• 1、 -. "CYCLOPROPANE COMPOUND". Page/Page column 160. . Retrieved 2012/04/23.
• 2、 Ellingboe, John W.,Collini, Michael D.,Quagliato, Dominick,Chen, James,Antane, Madelene,Schmid, Jean,Hartupee, Dale,White, Valerie,Park, C. Hyung,Tanikella, Tarak,Bagli, Jehan F.. "Metabolites of the angiotensin II antagonist tasosartan: The importance of a second acidic group". . p. 4251 - 4260. Retrieved 2007/10/03.