4-(4'-hydroxy-phenylaMino)-4-oxo-butanoic acid

Base Information

• Chemical Name: 4-(4'-hydroxy-phenylaMino)-4-oxo-butanoic acid
• CAS No.: 62558-67-2
• Molecular Formula: C10H11NO4
• Molecular Weight: 209.202
• Hs Code.: 2924299090
• Mol file: 62558-67-2.mol

Synonyms:Bernsteinsaeure-p-hydroxy-anilid;CCG-598;Succinic Acid p-Hydroxyphenylamide;

Chemical Property of 4-(4'-hydroxy-phenylaMino)-4-oxo-butanoic acid

Chemical Property:

• PSA: 86.63000
• LogP: 1.26850
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-((4-hydroxyphenyl)amino)-4-oxobutanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4'-hydroxy-phenylaMino)-4-oxo-butanoic acid

There total 6 articles about 4-(4'-hydroxy-phenylaMino)-4-oxo-butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

succinic acid anhydride (108-30-5) + 4-amino-phenol (123-30-8) → 4-(4'-hydroxy-phenylamino)-4-oxo-butanoic acid (62558-67-2)

Guidance literature:

With sodium dodecyl-sulfate; In methanol; water; at 20 ℃; for 0.583333h;

DOI:10.1016/j.bmcl.2012.03.048

Reference yield:

α-ketoglutaric acid (328-50-7) + 1-chloro-4-nitroso-benzene (932-98-9) → 4-(4'-hydroxy-phenylamino)-4-oxo-butanoic acid (62558-67-2) + 4-amino-phenol (123-30-8) + 2-amino-5-chlorophenol (28443-50-7) + N-(4-chloro-2-hydroxyphenyl)succinamic acid (81576-13-8)

Guidance literature:

With thiamine pyrophosphate; α-ketoglutarate dehydrogenase; magnesium chloride; In ethanol; water; at 30 ℃; for 2h; KH₂PO₄ buffer;

Reference yield:

1-chloro-4-nitroso-benzene (932-98-9) + α-ketoglutaric acid disodium salt (305-72-6) → 4-(4'-hydroxy-phenylamino)-4-oxo-butanoic acid (62558-67-2) + 4-amino-phenol (123-30-8) + 2-amino-5-chlorophenol (28443-50-7) + N-(4-chloro-2-hydroxyphenyl)succinamic acid (81576-13-8)

Guidance literature:

With thiamine pyrophosphate; α-ketoglutarate dehydrogenase; magnesium chloride; In water; at 30 ℃; for 2h; Further byproducts given. Yields of byproduct given; 0.05M KH₂PO₄ buffer (pH 7.5);

upstream raw materials:

succinic acid anhydride

4-amino-phenol

α-ketoglutaric acid

1-chloro-4-nitroso-benzene

Downstream raw materials:

4-(pyrrolidine-2,5–dione–1-yl)phenol

C₃₀H₃₁N₅O₆

Refernces

• 1、 Park, Sangeun,Hyun, Soonsil,Yu, Jaehoon. "Selective α-glucosidase substrates and inhibitors containing short aromatic peptidyl moieties". supporting information; experimental part. p. 2441 - 2444. Retrieved 2011/06/17.
• 2、 Trujillo-Ferrara,Vazquez, Ivan,Espinosa, Judith,Santillan, Rosa,Farfan, Norberto,Hoepfl, Herbert. "Reversible and irreversible inhibitory activity of succinic and maleic acid derivatives on acetylcholinesterase". . p. 313 - 322. Retrieved 2007/10/03.