3-HYDROXY-4-PYRIDINECARBOXYLIC ACID

Base Information

• Chemical Name: 3-HYDROXY-4-PYRIDINECARBOXYLIC ACID
• CAS No.: 10128-71-9
• Molecular Formula: C6H5NO3
• Molecular Weight: 139.111
• Hs Code.: 29333990
• Mol file: 10128-71-9.mol

Synonyms:3-hydroxypyridine-4-carboxylate;3-Hydroxyisonicotinic acid;3-Hydroxypyridine-4-carboxylicacid;3-Hydroxy-4-pyridinecarboxylic acid;

Chemical Property of 3-HYDROXY-4-PYRIDINECARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 1.3E-11mmHg at 25°C
• Melting Point: 317-319 °C(dec.)
• Boiling Point: 519.3 °C at 760 mmHg
• PKA: 0.51±0.10(Predicted)
• Flash Point: 267.9 °C
• PSA: 70.42000
• Density: 1.485 g/cm³
• LogP: 0.48540
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility.: Soluble in methanol. Slightly soluble in water.

Purity/Quality:

98% ^*data from raw suppliers

3-Hydroxyisonicotinic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Hydroxyisonicotinic Acid is used in the preparation of chelating agents for iron and aluminum.

Technology Process of 3-HYDROXY-4-PYRIDINECARBOXYLIC ACID

There total 12 articles about 3-HYDROXY-4-PYRIDINECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-Aminopyridine-4-carboxylic acid (7579-20-6) → 3-hydroxyisonicotinic acid (10128-71-9)

Guidance literature:

3-Aminopyridine-4-carboxylic acid; With sulfuric acid; sodium nitrite; In water; at 10 - 80 ℃;

With water; acetic acid; at 65 ℃;

With ammonia; In water; pH=~ 4.5;

Reference yield: 80.0%

furo<2,3-c>pyridinium 3-hydroxypyridine-4-nitrolate (92404-81-4) → 3-hydroxyisonicotinic acid (10128-71-9)

Guidance literature:

With hydrogenchloride; for 16h; Heating;

Reference yield: 80.0%

3-hydroxy-4-(1'-chloro-1'-hydroximinomethyl)pyridinium nitrate (92404-80-3) → 3-hydroxyisonicotinic acid (10128-71-9)

Guidance literature:

With hydrogenchloride; for 16h; Heating;

upstream raw materials:

3-chloro-isonicotinic acid

furo<2,3-c>pyridinium 3-hydroxypyridine-4-nitrolate

3-hydroxy-4-(1'-chloro-1'-hydroximinomethyl)pyridinium nitrate

5-ethoxyoxazole

Downstream raw materials:

methyl 3-hydroxypyridine-4-carboxylate

3-acetoxy-isonicotinic acid

3-HYDROXYPYRIDINE

3-chloro-isonicotinic acid amide

Refernces

• 1、 Brun, Paola,Dean, Annalisa,Di Marco, Valerio,Surajit, Pathak,Castagliuolo, Ignazio,Carta, Davide,Ferlin, Maria Grazia. "Peroxisome proliferator-activated receptor-γ mediates the anti-inflammatory effect of 3-hydroxy-4-pyridinecarboxylic acid derivatives: Synthesis and biological evaluation". . p. 486 - 497. Retrieved 2013.
• 2、 Okawa, Tomohiro,Aramaki, Yoshio,Yamamoto, Mitsuo,Kobayashi, Toshitake,Fukumoto, Shoji,Toyoda, Yukio,Henta, Tsutomu,Hata, Akito,Ikeda, Shota,Kaneko, Manami,Hoffman, Isaac D.,Sang, Bi-Ching,Zou, Hua,Kawamoto, Tetsuji. "Design, Synthesis, and Evaluation of the Highly Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure". . p. 6942 - 6990. Retrieved 2017/09/07.