2-(2-Pyridyl)benzoxazole

Base Information

• Chemical Name: 2-(2-Pyridyl)benzoxazole
• CAS No.: 32959-62-9
• Molecular Formula: C12H8 N2 O
• Molecular Weight: 196.208
• Hs Code.: 2934999090
• Mol file: 32959-62-9.mol

Synonyms:Benzoxazole,2-(2-pyridyl)- (8CI); 2-(2-Benzoxazolyl)pyridine; 2-(2-Pyridyl)benzoxazole;2-(2'-Pyridyl)benzoxazole; 2-(Pyridin-2-yl)benzo[d]oxazole

Chemical Property of 2-(2-Pyridyl)benzoxazole

Chemical Property:

• Vapor Pressure: 0.000607mmHg at 25°C
• Melting Point: 101.0 to 105.0 °C
• Boiling Point: 320.1°Cat760mmHg
• PKA: 1.74±0.19(Predicted)
• Flash Point: 146.9°C
• PSA: 38.92000
• Density: 1.241g/cm³
• LogP: 2.88980
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: slightly sol. in Toluene

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(2-Pyridyl)benzoxazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-Pyridyl)benzoxazole

There total 5 articles about 2-(2-Pyridyl)benzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(E)-2-pyridylphenyl ketoxime (14178-31-5) → pyridine (110-86-1) + [2,2]bipyridinyl (366-18-7) + 2-(2'-pyridyl)benzoxazole (32959-62-9) + benzonitrile (100-47-0)

Guidance literature:

at 800 ℃; for 8.33333E-06h; under 0.001 Torr; Further byproducts given;

Reference yield: 77.0%

(E)-2-pyridylphenyl ketoxime (14178-31-5) → pyridine (110-86-1) + 2-Cyanopyridine (100-70-9,1232006-36-8) + [2,2]bipyridinyl (366-18-7) + 2-(2'-pyridyl)benzoxazole (32959-62-9) + benzonitrile (100-47-0) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1)

Guidance literature:

at 800 ℃; under 0.001 - 0.01 Torr; approximate contact time: 0.002-0.03 s;

Reference yield:

2-(2-phenylethynyl)pyridine (13141-42-9) + 2-amino-phenol (95-55-6) → 2-phenylbenzo[d]oxazole (833-50-1) + 2-(2'-pyridyl)benzoxazole (32959-62-9)

Guidance literature:

With palladium dichloride; In chlorobenzene; for 10h; Overall yield = 81 %; Reflux;

DOI:10.1039/c3gc42499e

upstream raw materials:

(E)-2-pyridylphenyl ketoxime

(2-metoxy-phenyl)-pyridin-2-ylmethylene-amine

2-(2-phenylethynyl)pyridine

2-amino-phenol

Downstream raw materials:

[Re(OPPh₃)Cl₃(2-(2-pyridyl)benzoxazole))]

Refernces

• 1、 Xie, Hou-Zhi,Gao, Qi,Liang, Ying,Wang, Heng-Shan,Pan, Ying-Ming. "Palladium-catalyzed synthesis of benzoxazoles by the cleavage reaction of carbon-carbon triple bonds with o-aminophenol". supporting information. p. 2132 - 2135. Retrieved 2014/04/17.
• 2、 Ohsawa, Akio,Kawaguchi Takayuki,Igeta Hiroshi. "Flash Vacuum Pyrolysis of Aromatic Oximes". . p. 4352 - 4358. Retrieved 2007/10/02.