3-PHENOXYCINNAMIC ACID

Base Information

• Chemical Name: 3-PHENOXYCINNAMIC ACID
• CAS No.: 77124-20-0
• Molecular Formula: C15H12O3
• Molecular Weight: 240.258
• Hs Code.: 2918990090
• Mol file: 77124-20-0.mol

Synonyms:(E)-3-(3-phenoxyphenyl)acrylic acid;3-phenoxycinnamic acid;(E)-3-(3-phenoxyphenyl)-2-propenoic acid;m-phenoxycinnamic acid;3-phenoxy-trans-cinnamic acid;E-3-(3-phenoxyphenyl)propenoic acid;3'-Phenoxy-(E)-cinnamic Acid;

Chemical Property of 3-PHENOXYCINNAMIC ACID

Chemical Property:

• Melting Point: 114-115
• PSA: 46.53000
• LogP: 3.57670

Purity/Quality:

98%min ^*data from raw suppliers

trans-3-Phenoxycinnamic acid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-PHENOXYCINNAMIC ACID

There total 18 articles about 3-PHENOXYCINNAMIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(trimethylsilyl)ketene bis(trimethylsilyl) acetal (65946-59-0) + 3-Phenoxybenzaldehyde (39515-51-0) → (E)-3-(3-phenoxyphenyl)acrylic acid (77124-20-0)

Guidance literature:

(trimethylsilyl)ketene bis(trimethylsilyl) acetal; 3-Phenoxybenzaldehyde; With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

With ammonium chloride; In water;

DOI:10.1081/SCC-100103529

Reference yield: 91.0%

malonic acid (141-82-2) + 3-Phenoxybenzaldehyde (39515-51-0) → (E)-3-(3-phenoxyphenyl)acrylic acid (77124-20-0)

Guidance literature:

With piperidine; pyridine; at 120 ℃; for 3h;

DOI:10.1016/j.ejmech.2019.111723

Reference yield: 49.0%

malonic acid (141-82-2) + meta-hydroxybenzaldehyde (100-83-4) → (E)-3-(3-phenoxyphenyl)acrylic acid (77124-20-0)

Guidance literature:

With piperidine; In triethylamine; at 90 ℃; for 2h;

DOI:10.1039/d1md00175b

upstream raw materials:

acetic anhydride

3-Phenoxybenzaldehyde

chloroacetic acid

malonic acid

Downstream raw materials:

α-(m-Phenoxy)phenyl-β-nitroethene

methyl 3-<(4-phenoxy)phenyl>propenoate

3-(3-phenoxyphenyl)propan-1-ol

1-(3-iodopropyl)-3-phenoxybenzene

Refernces

• 1、 Kozlov, Maxim V.,Konduktorov, Konstantin A.,Malikova, Alsu Z.,Kamarova, Kamila A.,Shcherbakova, Anastasia S.,Solyev, Pavel N.,Kochetkov, Sergey N.. "Structural isomers of cinnamic hydroxamic acids block HCV replication via different mechanisms". . . Retrieved 2019/09/30.
• 2、 Lu, Min,Zhou, Shuwen,Guan, Jing,Xu, Xing,Fan,Xu, Defeng. "Synthesis of key intermediate of phosphonosulfonates (BPH-652), 1-(3-iodopropyl)-3-phenoxy benzene". . p. 7619 - 7621. Retrieved 2015/02/02.