4-METHOXYPHTHALONITRILE

Base Information

• Chemical Name: 4-METHOXYPHTHALONITRILE
• CAS No.: 80323-72-4
• Molecular Formula: C9H6N2O
• Molecular Weight: 158.159
• Mol file: 80323-72-4.mol

Synonyms:4-METHOXYISOPHALONITRILE;4-methoxyphthalonitrile;1,2-Benzenedicarbonitrile,4-Methoxy;4-Methoxyphthalodinitril;

Chemical Property of 4-METHOXYPHTHALONITRILE

Chemical Property:

• Vapor Pressure: 0.000381mmHg at 25°C
• Melting Point: 205-209oC(lit.)
• Boiling Point: 317.6oC at 760 mmHg
• Flash Point: 137.4oC
• PSA: 56.81000
• Density: 1.19g/cm3
• LogP: 1.43856

Purity/Quality:

98%Min ^*data from raw suppliers

4-METHOXYISOPHTHALONITRILE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 22-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHOXYPHTHALONITRILE

There total 4 articles about 4-METHOXYPHTHALONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

zinc(II) cyanide (557-21-1) + 3,4-dibromoanisole (62415-74-1) → 4-methoxyphthalonitrile (80323-72-4)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; polymethylhydroxysilane; In N,N-dimethyl acetamide; at 110 ℃; for 1.5h;

DOI:10.1055/s-2008-1078269

Reference yield: 82.0%

methanol (67-56-1) + 4-Nitrophthalonitrile (31643-49-9) → 4-methoxyphthalonitrile (80323-72-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 25h; Ambient temperature;

Reference yield: 54.0%

3,4-dibromoanisole (62415-74-1) + copper(I) cyanide (544-92-3) → 4-methoxyphthalonitrile (80323-72-4)

Guidance literature:

In N,N-dimethyl-formamide; at 145 - 150 ℃; for 4h;

upstream raw materials:

methanol

4-Nitrophthalonitrile

3,4-dibromoanisole

copper(I) cyanide

Downstream raw materials:

5-methoxy-isoindoline-1,3-dione-1,3-diimine

Refernces

• 1、 Yslas, E. Inés,Rivarola, Viviana,Durantini, Edgardo N.. "Synthesis and photodynamic activity of zinc(II) phthalocyanine derivatives bearing methoxy and trifluoromethylbenzyloxy substituents in homogeneous and biological media". . p. 39 - 46. Retrieved 2005.
• 2、 Iqbal, Zafar,Lyubimtsev, Alexey,Hanack, Michael. "Synthesis of phthalonitriles using a palladium catalyst". experimental part. p. 2287 - 2290. Retrieved 2009/05/07.