Adx-47273

Base Information

• Chemical Name: Adx-47273
• CAS No.: 851881-60-2
• Molecular Formula: C₂₀H₁₇F₂N₃O₂
• Molecular Weight: 369.371
• UNII: 4C4P7L0W63
• ChEMBL ID: CHEMBL381055
• DSSTox Substance ID: DTXSID80234386
• Nikkaji Number: J2.897.723I
• Pharos Ligand ID: TD15SL3H2K3L
• Wikidata: Q4651211
• Wikipedia: ADX-47273
• Mol file: 851881-60-2.mol

Synonyms:ADX 47273;ADX-47273;ADX47273;S-(4-fluorophenyl)-(3-(3-(4-fluorophenyl)-(1,2,4)-oxadiazol-5-yl)piperidin-1-yl)methanone

Chemical Property of Adx-47273

Chemical Property:

• PSA: 59.23000
• Density: 1.311
• LogP: 3.97250
• Solubility.: Soluble in DMSO
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 369.12888312
• Heavy Atom Count: 27
• Complexity: 508

Purity/Quality:

99%, ^*data from raw suppliers

ADX 47273 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(CN(C1)C(=O)C2=CC=C(C=C2)F)C3=NC(=NO3)C4=CC=C(C=C4)F
• Isomeric SMILES: C1C[C@@H](CN(C1)C(=O)C2=CC=C(C=C2)F)C3=NC(=NO3)C4=CC=C(C=C4)F
• Description: ADX-47273 is a positive allosteric modulator of metabotropic glutamate receptor 5 (mGluR5) with EC50 values of 0.17 and 0.23 μM for potentiation of glutamate activity in HEK293 cells expressing rat mGluR5 and primary astrocyte cultures, respectively. It is selective for mGluR5 over rat mGluR1 and human mGluR1 and mGluR4 when used at concentrations up to 10 μM. In vivo, ADX-47273 (1 and 10 mg/kg, i.p.) increases ERK and CREB phosphorylation in the hippocampus and prefrontal cortex in rats. It decreases the conditioned avoidance response, apomorphine-induced climbing, as well as PCP-, apomorphine-, and amphetamine-induced locomotor activity in rats in a dose-dependent manner, indicating antipsychotic-like activity. ADX-47273 (0.1-50 mg/kg, i.p) improves recall in a novel object recognition test and reduces impulsivity in the 5-choice serial reaction time task (5CSRTT). It also enhances reversal learning in mice in the Morris water maze test.

Technology Process of Adx-47273

There total 1 articles about Adx-47273 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

→ (4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-methanone (851881-60-2)

Guidance literature:

Refernces