4-bromo-2-ethylbenzenemethanol

Base Information

• Chemical Name: 4-bromo-2-ethylbenzenemethanol
• CAS No.: 877131-21-0
• Molecular Formula: C9H11BrO
• Molecular Weight: 215.09
• Mol file: 877131-21-0.mol

Synonyms:4-BROMO-2-ETHYLBENZENEMETHANOL;(4-bromo-2-ethyl-phenyl)-methanol;

Chemical Property of 4-bromo-2-ethylbenzenemethanol

Chemical Property:

• PSA: 20.23000
• LogP: 2.50380

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-2-ethylbenzenemethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-bromo-2-ethylbenzenemethanol

There total 4 articles about 4-bromo-2-ethylbenzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl 4-bromo-2-ethylbenzoate (194487-79-1) → (4-bromo-2-ethylphenyl)methanol (877131-21-0)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at -78 - 0 ℃; Inert atmosphere;

Reference yield: 89.0%

4-bromo-2-ethylbenzoic acid (644984-78-1) → (4-bromo-2-ethylphenyl)methanol (877131-21-0)

Guidance literature:

4-bromo-2-ethylbenzoic acid; With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; for 15.5h;

With water; In tetrahydrofuran;

Reference yield:

2-fluoro-4-bromobenzoic acid (112704-79-7) → (4-bromo-2-ethylphenyl)methanol (877131-21-0)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

3: diisobutylaluminium hydride / tetrahydrofuran; toluene / -78 - 0 °C / Inert atmosphere

With diisobutylaluminium hydride; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

upstream raw materials:

4-bromo-2-ethylbenzoic acid

4-bromo-2-methylbenzoic acid

methyl 4-bromo-2-ethylbenzoate

2-fluoro-4-bromobenzoic acid

Downstream raw materials:

2-(4-bromo-2-ethylbenzyl)isoindoline-1,3-dione

methyl 2-(4-bromo-2-ethylphenyl)acetate

2-(4-bromo-2-ethylphenyl)acetic acid

2-(4-bromo-2-ethylphenyl)acetonitrile

Refernces

• 1、 -. "BENZOFURANE AND BENZOTHIOPHENE DERIVATIVES AS PGE2 RECEPTOR MODULATORS". . . Retrieved 2018/12/13.
• 2、 -. "PHENYL DERIVATIVES AS PGE2 RECEPTOR MODULATORS". . . Retrieved 2018/12/13.