Sodium thioglycolate

Base Information

• Chemical Name: Sodium thioglycolate
• CAS No.: 367-51-1
• Molecular Formula: C2H4NaO2S
• Molecular Weight: 114.1
• Hs Code.: 29309070
• Mol file: 367-51-1.mol

Synonyms:Sodium 2-mercaptoethanoate;Sodium 2-sulfanylacetate;Sodium mercaptoacetate;Thioglycolic acid sodium salt;Aceticacid, mercapto-, monosodium salt (8CI,9CI);Mercaptoacetic acidsodium salt;

Chemical Property of Sodium thioglycolate

Chemical Property:

• Appearance/Colour: White solid
• Vapor Pressure: 0.0314mmHg at 25°C
• Melting Point: >300 °C(lit.)
• Boiling Point: 225.5 °C at 760 mmHg
• PKA: 3.82[at 20 ℃]
• Flash Point: 99.8 °C
• PSA: 78.93000
• Density: 1.311g/cm3
• LogP: -1.33390
• Storage Temp.: 2-8°C
• Sensitive.: Air Sensitive & Hygroscopic
• Solubility.: 609.1g/l
• Water Solubility.: soluble

Purity/Quality:

99% ^*data from raw suppliers

Thioglycolic Acid, Sodium Salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-38-36/37/38
• Safety Statements: 36-28-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: dipilatory, irritant, chelating agent In cold-waving of hair; as depilatory; in bacteriology for the preparation of thioglycolate media; as analytical reagent, see Thioglycolic Acid. Sodium thioglycolate has been used:as a growth supplement in enrichment media and to study its effect on Arcobacterin influenza hemagglutinin formulation in order to reduce disulfide-mediated cross-linking and early potency lossin electron microscopy

Technology Process of Sodium thioglycolate

There total 6 articles about Sodium thioglycolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

sodium isopropylxanthate (140-93-2) + ethylamine (75-04-7,85404-22-4) + chloroacetic acid (79-11-8) → O-isopropyl-N-ethylthionocarbamate (141-98-0) + sodium 2-mercaptoacetate (367-51-1)

Guidance literature:

sodium isopropylxanthate; chloroacetic acid; With sodium carbonate; In water; at 80 ℃; for 2h; pH=8;

ethylamine; In water; at 20 - 70 ℃; for 1h;

Reference yield:

mercaptoacetic acid (68-11-1) → sodium 2-mercaptoacetate (367-51-1)

Guidance literature:

With sodium hydroxide; In water; pH=10.2;

Reference yield:

chloroacetic acid (79-11-8) → sodium 2-mercaptoacetate (367-51-1)

Guidance literature:

chloroacetic acid; With sodium carbonate; In water;

With sodium thiosulfate; at 80 ℃;

With sodium hydroxide; at 20 ℃; Temperature;

upstream raw materials:

sodium hydroxide

mercaptoacetic acid

chloroacetic acid

sodium isopropylxanthate

Downstream raw materials:

(4-formyl-5-methyl-2-phenyl-2H-pyrazol-3-ylsulfanyl)-acetic acid

2-(4-methoxy-3-nitrobenzylthio)acetic acid

S-benzylmercaptoacetic acid

N-benzoyl-S-(2-carboxymethyl)dithiocarbamate

Refernces

• 1、 -. "Pyrimido azacyclo compound and application thereof". Paragraph 0045; 0052-0053. . Retrieved 2020/07/13.
• 2、 -. "Production method of high-grade sodium thioglycollate powder". Paragraph 0023-0029. . Retrieved 2017/01/17.