4-Morpholineacetic acid, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 4-Morpholineacetic acid, 1,1-dimethylethyl ester
• CAS No.: 88217-68-9
• Molecular Formula: C10H19NO3
• Molecular Weight: 201.266
• DSSTox Substance ID: DTXSID30439960
• Nikkaji Number: J1.230.796I
• Wikidata: Q82256077
• Mol file: 88217-68-9.mol

Synonyms:tert-Butyl 2-morpholinoacetate;88217-68-9;4-Morpholineacetic acid, 1,1-dimethylethyl ester;Tert-butyl 2-morpholin-4-ylacetate;SCHEMBL12014405;DTXSID30439960;WXTYDUYMAJETOH-UHFFFAOYSA-N;ZB1212;Morpholinoacetic acid tert-butyl ester;TERT-BUTYL 2-(MORPHOLIN-4-YL)ACETATE;(4-Morpholinyl)acetic Acid, 1,1-Dimethylethyl Ester

Chemical Property of 4-Morpholineacetic acid, 1,1-dimethylethyl ester

Chemical Property:

• XLogP3: 0.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 201.13649347
• Heavy Atom Count: 14
• Complexity: 192

Purity/Quality:

≥99.0% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)CN1CCOCC1

Technology Process of 4-Morpholineacetic acid, 1,1-dimethylethyl ester

There total 1 articles about 4-Morpholineacetic acid, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(benzoyloxy)morpholine (5765-65-1) + acetic acid tert-butyl ester (540-88-5) → tert-butyl benzoylacetate (54441-66-6) + (4-morpholinyl)acetic acid 1,1-dimethylethyl ester (88217-68-9)

Guidance literature:

acetic acid tert-butyl ester; With bis(2,2,6,6-tetramethyl-1-piperidyl)zinc; In toluene; at 20 ℃; for 1h; Microwave irradiation;

4-(benzoyloxy)morpholine; With [2,2]bipyridinyl; copper(l) cyanide; In tetrahydrofuran; toluene; at 20 ℃; for 24h; Reagent/catalyst; Microwave irradiation;

DOI:10.1039/c3cc49296f

Reference yield: 100.0%

(4-morpholinyl)acetic acid 1,1-dimethylethyl ester (88217-68-9) → morpholin-4-ylacetic acid (3235-69-6)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1016/S0040-4039(99)02157-7

Reference yield: 99.0%

(4-morpholinyl)acetic acid 1,1-dimethylethyl ester (88217-68-9) → N-(carboxymethyl)morpholine hydrochloride (89531-58-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 12h;

upstream raw materials:

4-(benzoyloxy)morpholine

acetic acid tert-butyl ester

Downstream raw materials:

morpholin-4-ylacetic acid

C₄₁H₅₁N₅O₈S

N-(carboxymethyl)morpholine hydrochloride

Refernces