3-Chloro-6-methoxy-4-methylpyridazine

Base Information

• Chemical Name: 3-Chloro-6-methoxy-4-methylpyridazine
• CAS No.: 89466-36-4
• Molecular Formula: C6H7ClN2O
• Molecular Weight: 158.58600
• Hs Code.: 2933990090
• European Community (EC) Number: 883-028-3
• Nikkaji Number: J786.784K
• Mol file: 89466-36-4.mol

Synonyms:3-Chloro-6-methoxy-4-methylpyridazine;89466-36-4;SCHEMBL4097986;KKUVFQSMYKCFAB-UHFFFAOYSA-N;AKOS022178316;CS-0212370;EN300-6209452

Chemical Property of 3-Chloro-6-methoxy-4-methylpyridazine

Chemical Property:

• Melting Point: 66 °C
• Boiling Point: 303.2±37.0 °C(Predicted)
• PKA: 1.65±0.10(Predicted)
• PSA: 35.01000
• Density: 1.237±0.06 g/cm3(Predicted)
• LogP: 1.44700
• Storage Temp.: 2-8°C
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 158.0246905
• Heavy Atom Count: 10
• Complexity: 112

Purity/Quality:

95% ^*data from raw suppliers

3-Chloro-6-methoxy-4-methylpyridazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NN=C1Cl)OC

Technology Process of 3-Chloro-6-methoxy-4-methylpyridazine

There total 3 articles about 3-Chloro-6-methoxy-4-methylpyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,6-dichloro-4-methylpyridazine (19064-64-3) + sodium methylate (124-41-4) → 3-chloro-6-methoxy-4-methylpyridazine (89466-36-4) + 6-chloro-3-methoxy-4-methylpyridazine (89466-38-6)

Guidance literature:

With methanol;

Reference yield:

3-chloro-6-methoxypyridazine (1722-10-7) + methyl iodide (74-88-4) → 3-chloro-6-methoxy-4-methylpyridazine (89466-36-4) + 6-chloro-3-methoxy-4-methylpyridazine (89466-38-6)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) hexane, 30 min, 0 degC, THF, 1.5 h, -70 degC; 2.) -70 degC, 2 h;

Reference yield:

→ 3-chloro-6-methoxy-4-methylpyridazine (89466-36-4)

Guidance literature:

4-Methyl-3,6-dichlor-pyridazin (2), NaOCH3/Me., Erhitzen; neben 6-Chlor-4-methyl-3-methoxy-pyridazin (III);

upstream raw materials:

3,6-dichloro-4-methylpyridazine

sodium methylate

3-chloro-6-methoxypyridazine

methyl iodide

Downstream raw materials:

2-(6-chloro-3-methoxy-5-methylpyridazin-4-yl)-N,N-diethyl-4-fluorobenzamide

5-methylpyridazin-3(2H)-one

6-chloro-5-methyl-2H-pyridazin-3-one

Refernces