cyclohexane-1,4-diyldimethanediyl diacetate

Base Information

• Chemical Name: cyclohexane-1,4-diyldimethanediyl diacetate
• CAS No.: 6308-18-5
• Molecular Formula: C12H20 O4
• Molecular Weight: 228.288
• Mol file: 6308-18-5.mol

Synonyms:1,4-Cyclohexanedimethanol,diacetate (7CI,8CI,9CI); 1,4-Dimethylolcyclohexane diacetate; NSC 43378; NSC97349

Chemical Property of cyclohexane-1,4-diyldimethanediyl diacetate

Chemical Property:

• Vapor Pressure: 0.00302mmHg at 25°C
• Boiling Point: 284.2°Cat760mmHg
• Flash Point: 131.5°C
• Density: 1.03g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of cyclohexane-1,4-diyldimethanediyl diacetate

There total 4 articles about cyclohexane-1,4-diyldimethanediyl diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

bis-1,4-(hydroxymethyl)cyclohexane (105-08-8) + acetic anhydride (108-24-7) → 1,4-cyclohexanedimethylene diacetate (6308-18-5)

Guidance literature:

With pyridine; at 125 ℃; for 3.5h; Reagent/catalyst; Large scale;

Reference yield: 87.0%

bis-1,4-(hydroxymethyl)cyclohexane (105-08-8) + acetyl chloride (75-36-5) → 1,4-cyclohexanedimethylene diacetate (6308-18-5)

Guidance literature:

With pyridine; dmap; In chloroform; at 0 - 20 ℃;

DOI:10.3390/molecules15053661

Reference yield: 75.0%

Isopropenyl acetate (108-22-5) + bis-1,4-(hydroxymethyl)cyclohexane (105-08-8) → 1,4-cyclohexanedimethylene diacetate (6308-18-5) + diisopropenyl 1,4-cyclohexanedimethanol ether + C13H22O3

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; sodium carbonate; In toluene; at 100 ℃; for 6h;

DOI:10.1021/jacs.6b02435

upstream raw materials:

bis-1,4-(hydroxymethyl)cyclohexane

acetyl chloride

Isopropenyl acetate

acetic anhydride

Downstream raw materials:

1,4-dimethylidenecyclohexane

trans-1,4-Cyclohexanedimethanol

Refernces

• 1、 Kar, Sayan,Luo, Jie,Rauch, Michael,Diskin-Posner, Yael,Ben-David, Yehoshoa,Milstein, David. "Dehydrogenative ester synthesis from enol ethers and water with a ruthenium complex catalyzing two reactions in synergy". supporting information. p. 1481 - 1487. Retrieved 2022/03/07.
• 2、 -. "SYNTHESIS OF BICYCLO(2.2.2)OCTANES". Paragraph 0040. . Retrieved 2018/05/15.