2-(2-METHOXYPHENYL)-3-PHENYLACRYLIC ACID

Base Information

• Chemical Name: 2-(2-METHOXYPHENYL)-3-PHENYLACRYLIC ACID
• CAS No.: 1657-65-4
• Molecular Formula: C16H14 O3
• Molecular Weight: 254.285
• Hs Code.: 2918990090
• Mol file: 1657-65-4.mol

Synonyms:Acrylicacid, 2-(o-methoxyphenyl)-3-phenyl-, (E)- (8CI); Benzeneacetic acid, 2-methoxy-a-(phenylmethylene)-, (E)-

Chemical Property of 2-(2-METHOXYPHENYL)-3-PHENYLACRYLIC ACID

Chemical Property:

• Vapor Pressure: 2.91E-06mmHg at 25°C
• Melting Point: 146-148°C
• Boiling Point: 374.2°Cat760mmHg
• Flash Point: 135.9°C
• PSA: 46.53000
• Density: 1.204g/cm³
• LogP: 3.32040
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-(2-Methoxyphenyl)-3-phenylacrylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-METHOXYPHENYL)-3-PHENYLACRYLIC ACID

There total 7 articles about 2-(2-METHOXYPHENYL)-3-PHENYLACRYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

Z-2-(o-methoxyphenyl)-3-phenyl propenoic acid (119460-67-2) → (E)-2-(2-methoxyphenyl)-3-phenylpropenoic acid (1657-65-4)

Guidance literature:

With aluminium trichloride; In dichloromethane; Ambient temperature;

Reference yield: 38.0%

2-methoxyphenylacetic acid (93-25-4) + benzaldehyde (100-52-7) → (E)-2-(2-methoxyphenyl)-3-phenylpropenoic acid (1657-65-4) + Z-2-(o-methoxyphenyl)-3-phenyl propenoic acid (119460-67-2)

Guidance literature:

With acetic anhydride; triethylamine; for 3h; Heating;

DOI:10.1080/00397910008087187

Reference yield:

(o-Methoxyphenyl)-phenylcyclopropenon (23074-50-2) → (E)-2-(2-methoxyphenyl)-3-phenylpropenoic acid (1657-65-4) + (E)-2-phenyl-3-(2-methoxyphenyl)propenoic acid (20890-72-6,25333-25-9,21140-85-2)

Guidance literature:

With water; In acetonitrile; at 30 ℃; Kinetics; Alkaline hydrolysis;

DOI:10.1135/cccc19991594

upstream raw materials:

Z-2-(o-methoxyphenyl)-3-phenyl propenoic acid

2-methoxyphenylacetic acid

benzaldehyde

(o-Methoxyphenyl)-phenylcyclopropenon

Downstream raw materials:

(Z)-3-benzylidene-3H-benzofuran-2-one

3-[1-phenyl-meth-(E)-ylidine]-3H-benzofuran-2-one

2-(2-methoxyphenyl)-3-phenylpropionic acid

2-(2-methoxyphenyl)-3-phenylpropionic acid

Refernces

• 1、 Szllsi, Gy?rgy,Hermán, Beáta,Szabados, Erika,Fül?p, Ferenc,Bartók, Mihály. "Reactions of chlorine substituted (E)-2,3-diphenylpropenoic acids over cinchonidine-modified Pd: Enantioselective hydrogenation versus hydrodechlorination". experimental part. p. 28 - 36. Retrieved 2011/02/24.
• 2、 Bowden, Keith,Burgess, Emma J.. "Reactions of carbonyl compounds in basic solutions. Part 34. The mechanism of the base-catalysed ring fission of 2,3-diphenylcycloprop-2-en-1-one". . p. 1594 - 1600. Retrieved 2007/10/03.