Acetophenone, 4'-(2-piperidinoethoxy)-

Base Information

• Chemical Name: Acetophenone, 4'-(2-piperidinoethoxy)-
• CAS No.: 2079-51-8
• Molecular Formula: C15H21NO2
• Molecular Weight: 247.337
• DSSTox Substance ID: DTXSID90174880
• Wikidata: Q83045035
• Mol file: 2079-51-8.mol

Synonyms:ACETOPHENONE, 4'-(2-PIPERIDINOETHOXY)-;1-[4-(2-piperidin-1-ylethoxy)phenyl]ethanone;2079-51-8;BRN 0170185;4'-(2-Piperidinoethoxy)acetophenone;Ethanone, 1-(4-(2-(1-piperidinyl)ethoxy)phenyl)-;4-20-00-00406 (Beilstein Handbook Reference);SCHEMBL12193816;DTXSID90174880;AKOS006025683

Chemical Property of Acetophenone, 4'-(2-piperidinoethoxy)-

Chemical Property:

• Vapor Pressure: 4.06E-06mmHg at 25°C
• Boiling Point: 384.6°Cat760mmHg
• Flash Point: 186.4°C
• Density: 1.052g/cm³
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 247.157228913
• Heavy Atom Count: 18
• Complexity: 253

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=CC=C(C=C1)OCCN2CCCCC2

Technology Process of Acetophenone, 4'-(2-piperidinoethoxy)-

There total 5 articles about Acetophenone, 4'-(2-piperidinoethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N-chloroethylpiperidine hydrochloride (2008-75-5) + 4-Hydroxyacetophenone (99-93-4) → 1-(4-(2-(piperidin-1-yl)ethoxy)phenyl)ethanone (2079-51-8)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; for 15h; Reflux;

DOI:10.1016/j.ejmech.2015.05.013

Reference yield: 40.0%

2-(piperidin-4-yl)ethyl chloride (1932-03-2) + 4-Hydroxyacetophenone (99-93-4) → 1-(4-(2-(piperidin-1-yl)ethoxy)phenyl)ethanone (2079-51-8)

Guidance literature:

With potassium carbonate; sodium iodide; In acetone; for 20h; Heating;

DOI:10.1016/S0223-5234(01)01292-2

Reference yield: 35.0%

1-piperidinoethanol (3040-44-6) + 4-(hydroxylmethyl)benzaldehyde (52010-97-6) → 1-(4-(2-(piperidin-1-yl)ethoxy)phenyl)ethanone (2079-51-8)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran;

upstream raw materials:

2-(piperidin-4-yl)ethyl chloride

4-Hydroxyacetophenone

piperidine

1-(4-(2-bromoethoxy)phenyl)ethan-1-one

Downstream raw materials:

3-(4-hydroxyphenylthio)-3-phenyl-1-(4-(2-(piperidin-1-yl)ethoxy)phenyl)propan-1-one

3-(3-hydroxyphenyl)-3-(4-hydroxyphenylthio)-1-(4-(2-(piperidin-1-yl)ethoxy)phenyl)propan-1-one

Refernces

• 1、 Leeza Zaidi, Saadia,Mittal, Sonam,Rajala, Maitreyi S.,Avecilla, Fernando,Husain, Mohammad,Azam, Amir. "Synthesis, characterization and antiamoebic activity of chalcones bearing N -substituted ethanamine tail". . p. 179 - 189. Retrieved 2015/06/08.
• 2、 Sharon, Ashoke,Pratap, Ramendra,Vatsyayan, Rit,Maulik, Prakas R.,Roy, Uma,Goel, Atul,Ram, Vishnu Ji. "6-Aryl-4-methylsulfanyl-2H-pyran-2-one-3-carbonitriles as PPAR-γ activators". . p. 3356 - 3360. Retrieved 2007/10/03.