2-chloro-1-[4-(2-chloroacetyl)piperazin-1-yl]ethanone

Base Information

• Chemical Name: 2-chloro-1-[4-(2-chloroacetyl)piperazin-1-yl]ethanone
• CAS No.: 1703-23-7
• Molecular Formula: C8H12 Cl2 N2 O2
• Molecular Weight: 239.101
• Hs Code.: 2933599090
• Mol file: 1703-23-7.mol

Synonyms:Piperazine,1,4-bis(chloroacetyl)- (6CI,7CI,8CI,9CI); 1,4-Bis(chloroacetyl)piperazine;Bis(chloroacetyl)piperazine; N,N'-Bis(chloroacetyl)piperazine; NSC 41263

Chemical Property of 2-chloro-1-[4-(2-chloroacetyl)piperazin-1-yl]ethanone

Chemical Property:

• Vapor Pressure: 1.54E-07mmHg at 25°C
• Boiling Point: 428.3°Cat760mmHg
• Flash Point: 212.8°C
• PSA: 40.62000
• Density: 1.375g/cm³
• LogP: 0.01060

Purity/Quality:

99% ^*data from raw suppliers

1,1'-(Piperazine-1,4-diyl)bis(2-chloroethanone) 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloro-1-[4-(2-chloroacetyl)piperazin-1-yl]ethanone

There total 3 articles about 2-chloro-1-[4-(2-chloroacetyl)piperazin-1-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

piperazine (110-85-0) + chloroacetyl chloride (79-04-9) → N,N'-bis(chloroacetyl)piperazine (1703-23-7)

Guidance literature:

With potassium carbonate; In chloroform; at 0 - 20 ℃; for 3h;

DOI:10.1021/jacs.5b09158

Reference yield:

piperazine dihydrochloride hydrate (6091-62-9,207605-49-0) + chloroacetyl chloride (79-04-9) → N,N'-bis(chloroacetyl)piperazine (1703-23-7)

Guidance literature:

With diethyl ether; sodium hydrogencarbonate;

Reference yield:

→ N,N'-bis(chloroacetyl)piperazine (1703-23-7)

Guidance literature:

DOI:10.1248/cpb.13.594

upstream raw materials:

piperazine

chloroacetyl chloride

piperazine dihydrochloride hydrate

Downstream raw materials:

1,4-bis-(2-chloro-ethyl)-piperazine

C₂₈H₂₆N₂O₄

N,N'-di(m-acetamidophenoxy)acetylpiperazine

N,N'-diacetylpiperazine

Refernces

• 1、 Ghosh, Kumaresh,Tarafdar, Debojyoti. "Piperazine-based new sensor: Selective ratiometric sensing of Fe3+, logic gate construction and cell imaging". . p. 224 - 232. Retrieved 2015.
• 2、 Ghosh, Kumaresh,Tarafdar, Debojyoti,Samadder, Asmita,Khuda-Bukhsh, Anisur Rahman. "Piperazine-based simple structure for selective sensing of Hg2+ and glutathione and construction of a logic circuit mimicking an INHIBIT gate". . p. 4206 - 4213. Retrieved 2013.
• 3、 Al-Dujaili, Ammar H.,Karam, Nisreen H.,Shanshal, Alaa K.. "Synthesis, characterization and study of mesomorphic behavior of new bent and linear core compounds containing heterocyclic rings". . . Retrieved 2021/08/20.
• 4、 Yu, Jing,Martins, André F.,Preihs, Christian,Clavijo Jordan, Veronica,Chirayil, Sara,Zhao, Piyu,Wu, Yunkou,Nasr, Khaled,Kiefer, Garry E.,Sherry, A. Dean. "Amplifying the Sensitivity of Zinc(II) Responsive MRI Contrast Agents by Altering Water Exchange Rates". supporting information. p. 14173 - 14179. Retrieved 2015/11/25.