2-Furanilide

Base Information

• Chemical Name: 2-Furanilide
• CAS No.: 1929-89-1
• Molecular Formula: C11H9NO2
• Molecular Weight: 187.198
• Hs Code.: 2932190090
• NSC Number: 3128
• DSSTox Substance ID: DTXSID4075160
• Nikkaji Number: J269.691F
• Wikidata: Q82003184
• ChEMBL ID: CHEMBL1568885
• Mol file: 1929-89-1.mol

Synonyms:N-phenylfuran-2-carboxamide;2-Furanilide;1929-89-1;N-Phenyl-2-furamide;2-Furancarboxamide, N-phenyl-;Furan-2-carboxylic acid phenylamide;N-phenyl-2-Furancarboxamide;furanilide;N-phenyl furamide;NSC3128;2-furancarboxanilide;N-Phenyl-2-furamide #;N~2~-phenyl-2-furamide;Oprea1_366727;Oprea1_617596;MLS001211749;SCHEMBL2997673;Aniline, N-(2-furylcarbonyl)-;CHEMBL1568885;DTXSID4075160;HMS1682E06;HMS2831F23;BAA92989;NSC 3128;NSC-3128;STK249528;AKOS000732860;NCGC00245019-01;SMR000504950;CS-0234060;FT-0717363;EN300-138388;F3147-2782

Chemical Property of 2-Furanilide

Chemical Property:

• Vapor Pressure: 0.129mmHg at 25°C
• Refractive Index: 1.62
• Boiling Point: 217.9 °C at 760 mmHg
• Flash Point: 85.6 °C
• PSA: 42.24000
• Density: 1.238 g/cm³
• LogP: 2.60490
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 187.063328530
• Heavy Atom Count: 14
• Complexity: 200

Purity/Quality:

99% ^*data from raw suppliers

N-phenylfuran-2-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)NC(=O)C2=CC=CO2

Technology Process of 2-Furanilide

There total 46 articles about 2-Furanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-furanoic acid (88-14-2) + aniline (62-53-3) → furan-2-carboxylic acid phenylamide (1929-89-1)

Guidance literature:

With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 5h;

DOI:10.1039/c9ob00699k

Reference yield: 95.0%

2-furoic acid methyl ester (611-13-2) + aniline (62-53-3) → furan-2-carboxylic acid phenylamide (1929-89-1)

Guidance literature:

With sodium t-butanolate; In neat (no solvent); at 20 ℃; for 1h; Inert atmosphere; Schlenk technique; Green chemistry;

DOI:10.1039/d1gc00720c

Reference yield: 90.0%

2-furancarbonyl chloride (527-69-5) + aniline (62-53-3) → furan-2-carboxylic acid phenylamide (1929-89-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In water; at 0 ℃; Micellar solution;

DOI:10.1021/acs.oprd.0c00303

upstream raw materials:

2-furancarbonyl chloride

aniline

2-furoic acid methyl ester

S-phenyl furan-2-carbothioate

Downstream raw materials:

furan-2-carbothioic acid anilide

5-bromo-furan-2-carboxylic acid-(4-bromo-anilide)

2-(furan-2-yl)-1,3-benzothiazole

5-(1,3-benzothiazol-2-yl)furan-2-carbaldehyde

Refernces

• 1、 Mansurov et al.. "-". . . Retrieved 1975.
• 2、 Qu, Erdong,Li, Shangzhang,Bai, Jin,Zheng, Yan,Li, Wanfang. "Nickel-Catalyzed Reductive Cross-Coupling of N-Acyl and N-Sulfonyl Benzotriazoles with Diverse Nitro Compounds: Rapid Access to Amides and Sulfonamides". supporting information. p. 58 - 63. Retrieved 2021/12/27.
• 3、 Wang, Kai,Hou, Jiahao,Wei, Tingting,Zhang, Changjun,Bai, Renren,Xie, Yuanyuan. "A metal-free picolinamide assisted electrochemical ortho-trifluoromethylation of arylamines". supporting information. . Retrieved 2020/12/21.