Technology Process of 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine tartrate
There total 5 articles about 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine tartrate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-(9,10-dihydro-6H-6,10-methanoazepino[4,5-g]quinoxaline-8(7H)-yl)-2,2,2,-trifluoroethanone;
With
sodium hydroxide;
In
water; toluene;
at 40 - 45 ℃;
for 2h;
Industry scale;
L-Tartaric acid;
In
methanol;
at 20 - 25 ℃;
for 1h;
Product distribution / selectivity;
Industry scale;
- Guidance literature:
-
In
methanol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: Amberlite IRA 67 / water; tetrahydrofuran / 0 - 30 °C
2: potassium carbonate / water; methanol / 4 h / 50 - 55 °C
3: methanol / 6 h / 25 - 30 °C
With
potassium carbonate;
In
tetrahydrofuran; methanol; water;
