(S)-2-Amino-4-methylvaleramide HCl

Base Information

• Chemical Name: (S)-2-Amino-4-methylvaleramide HCl
• CAS No.: 10466-61-2
• Molecular Formula: C6H14N2O^.HCl
• Molecular Weight: 166.651
• Hs Code.: 29241900
• Mol file: 10466-61-2.mol

Synonyms:EINECS 233-952-2;NSC 83635;(S)-2-Amino-4-methylvaleramide HCl;CCG-40477;AKOS003368705

Chemical Property of (S)-2-Amino-4-methylvaleramide HCl

Chemical Property:

• Appearance/Colour: White solid.
• Vapor Pressure: 0.0211mmHg at 25°C
• Melting Point: 254-256 °C
• Refractive Index: 9.8 ° (C=5, H2O)
• Boiling Point: 250.9 °C at 760 mmHg
• Flash Point: 105.6 °C
• PSA: 69.11000
• Density: 0.98g/cm3
• LogP: 2.04770
• Storage Temp.: Store at RT.
• Sensitive.: Hygroscopic
• Water Solubility.: very faint turbidity in Water
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 165.0794658
• Heavy Atom Count: 10
• Complexity: 101

Purity/Quality:

L-Leucine amide hydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)N)N.[Cl-]
• Uses: L-Leucinamide Hydrochloride, is a derivative of Leucine, which is an essential amino acid, and acts as a nutrient signal to stimulate protein synthesis. L-Leucinamide Hydrochloride, is shown to be the potential elicitors of insulin secretion in rats.

Technology Process of (S)-2-Amino-4-methylvaleramide HCl

There total 9 articles about (S)-2-Amino-4-methylvaleramide HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

methyl (L)-leucinate hydrochloride (7517-19-3) → (2S)-amino-4-methylpentanamide hydrochloride (10466-61-2)

Guidance literature:

methyl (L)-leucinate hydrochloride; With ammonia; In methanol; at 50 ℃; for 48h; Sealed tube;

With hydrogenchloride; In 1,4-dioxane; Sonication;

DOI:10.1016/j.bmcl.2016.09.001

Reference yield:

N-<3-(2-furyl)acryloyl>-Gly-Phe-NH2 (26400-34-0) → (2S)-amino-4-methylpentanamide hydrochloride (10466-61-2) + N-<3-(2-furyl)acryloyl>glycylphenylalanine (88874-25-3)

Guidance literature:

carboxypeptidase from yeast (CPase-Y); In dimethyl sulfoxide; at 30 ℃; for 3h; under 750060 Torr;

DOI:10.1246/bcsj.62.514

Reference yield:

2-(1,3-dicyano-5-isopropenyl-2-methyl-cyclohexylamino)-4-methyl-pentanoic acid amide → (2S)-amino-4-methylpentanamide hydrochloride (10466-61-2) + (R)-2-amino-4-methylpentanamide hydrochloride (80970-09-8)

Guidance literature:

With hydrogenchloride; In methanol; water; at 50 ℃; for 4h; pH=1; Title compound not separated from byproducts;

DOI:10.1002/ejoc.200600294

upstream raw materials:

H-Leu-NH₂*formate

Z(OMe)-Leu-NH₂

N-<3-(2-furyl)acryloyl>-Gly-Phe-NH2

methyl (L)-leucinate hydrochloride

Downstream raw materials:

Z-Ala-Tyr-Leu-NH₂

N-<3-(2-furyl)acryloyl>-Gly

N-<3-(2-furyl)acryloyl>-Gly-Leu-NH2

N¹-(1H-1,2,3-benzotriazol-1-ylmethyl)-N²-(4-morpholin-4-ylbenzoyl)leucinamide

Refernces

• 1、 Kunugi, Shigeru,Tanabe, Kazuo,Yamashita, Kouji,Morikawa, Yoshio,Ito, Takanobu,et al.. "Protease-Catalyzed Peptide Formation under High Pressure". . p. 514 - 518. Retrieved 1989.
• 2、 Hartke, Klaus,Barrmeyer, Stephan. "Synthesis of α-amino dithioesters and endothiodipeptides". . p. 251 - 256. Retrieved 2007/10/03.