(2-BROMOBENZYL)METHYLAMINE

Base Information

• Chemical Name: (2-BROMOBENZYL)METHYLAMINE
• CAS No.: 698-19-1
• Molecular Formula: C8H10BrN
• Molecular Weight: 200.078
• Hs Code.: 2921499090
• Mol file: 698-19-1.mol

Synonyms:Benzylamine,o-bromo-N-methyl- (7CI,8CI);(2-Bromobenzyl)methylamine;(Methyl)(2-bromobenzyl)amine;

Chemical Property of (2-BROMOBENZYL)METHYLAMINE

Chemical Property:

• Vapor Pressure: 0.0618mmHg at 25°C
• Refractive Index: n20/D 1.5670(lit.)
• Boiling Point: 231.6 °C at 760 mmHg
• PKA: 9.14±0.10(Predicted)
• Flash Point: 93.9 °C
• PSA: 12.03000
• Density: 1.358 g/cm³
• LogP: 2.55940
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Sensitive.: Air Sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Methyl-2-bromobenzylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-BROMOBENZYL)METHYLAMINE

There total 10 articles about (2-BROMOBENZYL)METHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.2%

ortho-bromobenzaldehyde (6630-33-7) + methylamine (74-89-5) → N-methyl-2-bromobenzylamine (698-19-1)

Guidance literature:

ortho-bromobenzaldehyde; methylamine; With 3 A molecular sieve; In methanol; at 20 ℃; for 24h;

With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.25h;

DOI:10.1248/cpb.50.441

Reference yield: 96.0%

→ N-methyl-2-bromobenzylamine (698-19-1)

Guidance literature:

With sodium tris(acetoxy)borohydride; In ethanol; dichloromethane; at 20 ℃; for 24h;

Reference yield: 95.0%

methylamine (74-89-5) + 1-Bromo-2-bromomethyl-benzene (3433-80-5) → N-methyl-2-bromobenzylamine (698-19-1)

Guidance literature:

In methanol; at 20 ℃; for 2h;

upstream raw materials:

2-bromo-N-methylbenzamide

methylamine

1-Bromo-2-bromomethyl-benzene

ortho-bromobenzaldehyde

Downstream raw materials:

N-(2-bromo-benzyl)-2-(2-cyano-1-methyl-1H-indol-3-yl)-N-methyl-acetamide

4-[N-methyl-N-(2-bromobenzyl)]amino-8-methylbenzopyran-7-one

4-[N-methyl-N-(2-bromo-5-methoxybenzyl)]amino-8-methylbenzopyran-7-one

4-[N-methyl,N-(2-bromobenzyl)]amino-6-tertiarybutylbenzopyran-7-one

Refernces

• 1、 Lebleu, Thomas,Ma, Xiaolu,Maddaluno, Jacques,Legros, Julien. "Selective monomethylation of primary amines with simple electrophiles". supporting information. p. 1836 - 1838. Retrieved 2014/02/14.
• 2、 Reddy, Alavala Gopi Krishna,Satyanarayana, Gedu. "A simple efficient sequential one-pot intermolecular aza-Michael addition and intramolecular Buchwald-Hartwig α-arylation of amines: Synthesis of functionalized tetrahydroisoquinolines". scheme or table. p. 8003 - 8010. Retrieved 2012/09/25.