Histidylhistidine

Base Information

• Chemical Name: Histidylhistidine
• CAS No.: 306-14-9
• Molecular Formula: C12H16 N6 O3
• Molecular Weight: 292.297
• European Community (EC) Number: 206-179-3
• DSSTox Substance ID: DTXSID401314242
• Nikkaji Number: J193.715D
• Wikidata: Q27144364
• Metabolomics Workbench ID: 78824
• ChEMBL ID: CHEMBL377872
• Mol file: 306-14-9.mol

Synonyms:His-His;histidylhistidine;histidylhistidine, (DL)-(DL)-isomer

Chemical Property of Histidylhistidine

Chemical Property:

• Melting Point: 248 °C
• Boiling Point: 853.3°Cat760mmHg
• PKA: 2.72±0.10(Predicted)
• Flash Point: 469.8°C
• PSA: 153.27000
• Density: 1.483g/cm³
• LogP: 0.35530
• XLogP3: -3.7
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 7
• Exact Mass: 292.12838839
• Heavy Atom Count: 21
• Complexity: 380

Purity/Quality:

99%, ^*data from raw suppliers

H-His-His-OHtrifluoroacetatesalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(NC=N1)CC(C(=O)NC(CC2=CN=CN2)C(=O)O)N
• Isomeric SMILES: C1=C(NC=N1)C[C@@H](C(=O)N[C@@H](CC2=CN=CN2)C(=O)O)N

Technology Process of Histidylhistidine

There total 9 articles about Histidylhistidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclo-(L-histidyl-L-histidyl) (16944-59-5) → L-histidyl-L-histidine (306-14-9)

Guidance literature:

With sodium hydroxide;

Reference yield:

→ L-histidyl-L-histidine (306-14-9)

Guidance literature:

With sodium hydroxide; at 25 ℃;

Reference yield:

L-histidine (71-00-1) → L-histidyl-L-histidine (306-14-9)

Guidance literature:

With dicyclohexyl-carbodiimide;

DOI:10.1248/cpb.28.2318

upstream raw materials:

cyclo-(L-histidyl-L-histidyl)

L-histidine

N(α)-t-butoxycarbonyl-N(?)-benzyloxymethyl-L-histidyl-N(?)-benzyloxymethyl-L-histidine methyl ester

N-[(1,1-dimethylethoxy)carbonyl]-3-[(phenylmethoxy)methyl]-L-histidine

Downstream raw materials:

H-Gly-NH₂

D,L-histidine

Refernces

• 1、 Takamura,Sakamoto,Ohashi. "Accelerating effect of histidylhistidine on the copper(II)-catalyzed oxidation of ascorbic acid". . p. 2318 - 2324. Retrieved 1980.