N-(4-(2-Hydroxyethoxy)phenyl)acetamide

Base Information

• Chemical Name: N-(4-(2-Hydroxyethoxy)phenyl)acetamide
• CAS No.: 50375-15-0
• Molecular Formula: C10H13 N O3
• Molecular Weight: 195.218
• Hs Code.: 2924299090
• European Community (EC) Number: 256-562-4
• DSSTox Substance ID: DTXSID3068544
• Nikkaji Number: J29.368G
• Wikidata: Q81995295
• ChEMBL ID: CHEMBL4472376
• Mol file: 50375-15-0.mol

Synonyms:50375-15-0;N-(4-(2-Hydroxyethoxy)phenyl)acetamide;N-[4-(2-hydroxyethoxy)phenyl]acetamide;N-[4-(hydroxyethoxy)phenyl]ethanamide;EINECS 256-562-4;Acetamide, N-[4-(2-hydroxyethoxy)phenyl]-;Acetamide, N-(4-(2-hydroxyethoxy)phenyl)-;2-[4-(acetylamino)phenoxy]ethanol;SCHEMBL92223;2-(4-acetamidophenoxy)ethanol;O-(2-Hydroxyethyl)paracetamol;CHEMBL4472376;DTXSID3068544;4'-(2-hydroxyethoxy)acetanilide;MFCD00020595;AKOS005073930;SS-3965;BETA-HYDROXY-PARA-ACETOPHENETIDIDE;N-[4-(2-hydroxyethoxy)phenyl]-acetamide;CS-0277260;FT-0681835;A871578;ACETAMIDE,N-[4-(2-HYDROXYETHOXY)PHENYL]-;J-523021;Z425795554

Chemical Property of N-(4-(2-Hydroxyethoxy)phenyl)acetamide

Chemical Property:

• Vapor Pressure: 2.99E-08mmHg at 25°C
• Boiling Point: 432.6°C at 760 mmHg
• Flash Point: 215.4°C
• PSA: 58.56000
• Density: 1.216g/cm³
• LogP: 1.08910
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 195.08954328
• Heavy Atom Count: 14
• Complexity: 176

Purity/Quality:

98%min ^*data from raw suppliers

N-[4-(2-Hydroxyethoxy)phenyl]acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=O)NC1=CC=C(C=C1)OCCO
• Uses: N-[4-(2-Hydroxyethoxy)phenyl]acetamide is an intermediate in the synthesis of N-[4-(2-Chloroethoxy)phenyl]-methanesulfonamide (C371290), which is an impurity of Dofetilide (D525700), a potassium channel blocker.

Technology Process of N-(4-(2-Hydroxyethoxy)phenyl)acetamide

There total 6 articles about N-(4-(2-Hydroxyethoxy)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Carbonic acid 2-(4-acetylamino-phenoxy)-ethyl ester benzyl ester (93930-27-9) → 2-[4-(acetylamino)phenoxy]ethanol (50375-15-0)

Guidance literature:

With sodium hypophosphite; palladium on activated charcoal; In tetrahydrofuran; water; at 50 ℃; for 6h;

DOI:10.1016/S0040-4039(01)81494-5

Reference yield: 84.6%

4-acetaminophenol (103-90-2,8055-08-1) + 2-chloro-ethanol (107-07-3) → 2-[4-(acetylamino)phenoxy]ethanol (50375-15-0)

Guidance literature:

With sodium hydroxide; at 60 - 70 ℃; for 8h;

DOI:10.1016/S0223-5234(01)01246-6

Reference yield: 77.0%

oxirane (75-21-8,99932-75-9) + 4-acetaminophenol (103-90-2,8055-08-1) → 2-[4-(acetylamino)phenoxy]ethanol (50375-15-0)

Guidance literature:

With sodium methylate; acetic acid; In ethyl acetate;

upstream raw materials:

oxirane

4-acetaminophenol

2-chloro-ethanol

Carbonic acid 2-(4-acetylamino-phenoxy)-ethyl ester benzyl ester

Downstream raw materials:

[4-(2-chloro-ethoxy)-phenyl]-(5-methoxy-benzothiazol-2-yl)-amine

acetic acid-[4-(2-diethylamino-ethoxy)-anilide]

N-(4-(2-(dimethylamino)ethoxy)phenyl)acetamide

acetic acid-[4-(2-piperidino-ethoxy)-anilide]

Refernces

• 1、 Villa, Stefania,Barlocco, Daniela,Cignarella, Giorgio,Papp, Gyula Julius,Balati, Beata,Takacs, Janos,Varro, Andras,Borosy, Andras,Keseru, Katalin,Matyus, Peter. "3,8-Diazabicyclo-[3.2.1]-octane derivatives as analogues of ambasilide, a Class III antiarrhythmic agent". . p. 495 - 506. Retrieved 2007/10/03.
• 2、 -. "5-Substituted pyrimidine derivatives active against internal animal parasites". . . Retrieved 2008/06/13.