2-METHOXYETHYL CHLOROFORMATE

Base Information

• Chemical Name: 2-METHOXYETHYL CHLOROFORMATE
• CAS No.: 628-12-6
• Molecular Formula: C4H7ClO3
• Molecular Weight: 138.551
• Hs Code.: 2915900090
• European Community (EC) Number: 211-026-9
• DSSTox Substance ID: DTXSID90211880
• Nikkaji Number: J150.176C
• Wikidata: Q63409852
• Mol file: 628-12-6.mol

Synonyms:Formicacid, chloro-, 2-methoxyethyl ester (6CI);(2-Methoxyethoxy)carbonyl chloride;2-(Methyloxy)ethyl chloroformate;2-Methoxyethyl chloroformate;Chloroformicacid 2-methoxyethyl ester;

Chemical Property of 2-METHOXYETHYL CHLOROFORMATE

Chemical Property:

• Appearance/Colour: Colorless to green Liquid
• Vapor Pressure: 4.71mmHg at 25°C
• Refractive Index: n20/D 1.4200(lit.)
• Boiling Point: 146.1 °C at 760 mmHg
• Flash Point: 54.9 °C
• PSA: 35.53000
• Density: 1.196 g/cm³
• LogP: 1.00820
• Storage Temp.: 2-8°C
• Sensitive.: Moisture Sensitive
• Solubility.: Soluble in most organic solvents.
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 138.0083718
• Heavy Atom Count: 8
• Complexity: 73.7

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Methoxyethyl chloroformate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Toxic Gases & Vapors -> Acid Halides
• Canonical SMILES: COCCOC(=O)Cl
• Uses: Reactant for:? ;Preparation of N-bridged bicyclic sulfonamides as inhibitors of γ-secretase1? ;Preparation of dimethoxyethyl azodicarboxylate via amidation/oxidation and application to Mitsunobu reaction2? ;Regioselective, stereoselective, and kinetically-controlled nickel-catalyzed cyanoesterification of allenes chloroformates and TMSCN3? ;Preparation of amino carboxamidobenzothiazoles as Lck inhibitors4? ;Preparation of nonracemic spirooxindoles using a stereoselective three-component coupling reaction as the key step and using acylation reactions to add st 2-methoxyethyl chloroformate was used to produce di-2-dimethoxyethyl hydrazine carboxylate(alternative reagent for the mitsunobu reaction).

Technology Process of 2-METHOXYETHYL CHLOROFORMATE

There total 6 articles about 2-METHOXYETHYL CHLOROFORMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

phosgene (75-44-5) + 2-methoxy-ethanol (109-86-4,95507-80-5) → 2-Methoxyethyl chloroformate (628-12-6)

Guidance literature:

In toluene; at 0 - 20 ℃;

DOI:10.1021/ja029931w

Reference yield: 30.0%

→ 2-Methoxyethyl chloroformate (628-12-6)

Guidance literature:

Reference yield:

2-methoxy-ethanol (109-86-4,95507-80-5) + bis(trichloromethyl) carbonate (32315-10-9) → 2-Methoxyethyl chloroformate (628-12-6)

Guidance literature:

With pyridine; In dichloromethane; for 0.166667h;

DOI:10.1023/B:PHAM.0000029281.12753.25

upstream raw materials:

phosgene

2-methoxy-ethanol

bis(trichloromethyl) carbonate

Downstream raw materials:

2-methoxyethyl carbamate

bis-(2-methoxy-ethoxycarbonyl)-peroxide

7-(2-methoxy-ethoxycarbonylamino)-3-phenyl-coumarin

4-(((2-methoxyethoxy)carbonyl)amino)benzoic acid

Refernces

• 1、 -. "NOVEL VINBLASTINE DERIVATIVES, THEIR PREPARATION, USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAID DERIVATIVES". Page/Page column 40. . Retrieved 2009/12/05.
• 2、 -. "MITOTIC KINESIN INHIBITORS AND METHODS OF USE THEREOF". Page/Page column 84. . Retrieved 2010/11/08.