n-Dodecylpyridin-2-amine

Base Information

• Chemical Name: n-Dodecylpyridin-2-amine
• CAS No.: 93812-57-8
• Molecular Formula: C₁₇H₃₀N₂
• Molecular Weight: 262.439
• NSC Number: 141143
• DSSTox Substance ID: DTXSID70917757
• Wikidata: Q82889469
• Mol file: 93812-57-8.mol

Synonyms:93812-57-8;n-dodecylpyridin-2-amine;NSC141143;SCHEMBL10607875;DTXSID70917757;NSC-141143

Chemical Property of n-Dodecylpyridin-2-amine

Chemical Property:

• Vapor Pressure: 5.05E-06mmHg at 25°C
• Boiling Point: 381.5°Cat760mmHg
• Flash Point: 184.5°C
• Density: 0.925g/cm³
• XLogP3: 6.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 12
• Exact Mass: 262.240898965
• Heavy Atom Count: 19
• Complexity: 182

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCCCCNC1=CC=CC=N1

Technology Process of n-Dodecylpyridin-2-amine

There total 6 articles about n-Dodecylpyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-aminopyridine (504-29-0) + 1-dodecyl alcohol (112-53-8) → N-dodecylpyridin-2-amine (93812-57-8)

Guidance literature:

With C₅₅H₄₃ClN₅P₂Ru⁽¹⁺⁾*Cl^(1-); potassium hydroxide; In toluene; at 140 ℃; for 2h; Sealed tube;

DOI:10.1002/ejoc.201700486

Reference yield: 58.0%

2-chloropyridine (109-09-1) + n-Dodecylamine (124-22-1) → N-dodecylpyridin-2-amine (93812-57-8)

Guidance literature:

With (C₅H₅)Fe(C₅H₃C(CH₃)NC₆H₄CH₃)PdCl(CN₂(C₆H₃(CH(CH₃)2)2)2C₂H₂); potassium tert-butylate; In 1,4-dioxane; at 110 ℃; for 3h; Inert atmosphere; Schlenk technique;

DOI:10.1002/aoc.3026

Reference yield: 45.0%

2-aminopyridine (504-29-0) + 1-Iodododecane (4292-19-7) → N-dodecylpyridin-2-amine (93812-57-8)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1246/bcsj.71.1973

upstream raw materials:

pyridine

n-Dodecylamine

2-aminopyridine

1-dodecylbromide

Refernces

• 1、 Mu, Bing,Li, Jingya,Wu, Yangjie. "Carbene adduct of cyclopalladated ferrocenylimine-assisted synthesis of aminopyridine derivatives by the amination of chloropyridines with primary and secondary amines". . p. 537 - 541. Retrieved 2013/09/23.