AURORA KA-3316

Base Information

• Chemical Name: AURORA KA-3316
• CAS No.: 1677-43-6
• Molecular Formula: C10H9NO2
• Molecular Weight: 175.187
• Hs Code.: 2933790090
• Mol file: 1677-43-6.mol

Synonyms:4-HYDROXY-7-METHYL-1H-QUINOLIN-2-ONE;4-HYDROXY-7-METHYL-2(1H)-QUINOLINONE;4-Hydroxy-7-methylquinolin-2(1H)-one;7-Methyl-4-hydroxy-carbostyril;4-HYDROXY-7-METHYL-1,2-DIHYDROQUINOLIN-2-ONE;

Chemical Property of AURORA KA-3316

Chemical Property:

• PSA: 49.66000
• LogP: 0.97740

Purity/Quality:

98.5% ^*data from raw suppliers

4-Hydroxy-7-methylquinolin-2(1H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AURORA KA-3316

There total 8 articles about AURORA KA-3316 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

malonic acid (141-82-2) + 1-amino-3-methylbenzene (108-44-1) → 4-hydroxy-7-methyl-1H-quinolin-2-one (1677-43-6)

Guidance literature:

In N,N-dimethyl-formamide; for 0.0666667h; microwave irradiation;

DOI:10.1016/j.bmcl.2006.09.082

Reference yield: 86.0%

N1,N3-di-m-tolylmalonamide (116476-70-1) → 4-hydroxy-7-methyl-1H-quinolin-2-one (1677-43-6)

Guidance literature:

With methanesulfonic acid; phosphorus pentoxide; at 150 - 170 ℃; for 1.33333h;

Reference yield:

3-bromo-7-methyl-quinoline-2,4-diol (50689-52-6) → 7-methyl-quinoline-2,4-diol (1677-43-6)

Guidance literature:

With sodium hydroxide; water; nickel; at 90 ℃;

DOI:10.1039/jr9580000614

upstream raw materials:

3-bromo-7-methyl-quinoline-2,4-diol

2-amino-7-methyl-quinolin-4-ol

2-amino-3-bromo-7-methyl-quinolin-4-ol

N₁,N₃-di-m-tolylmalonamide

Downstream raw materials:

2,4-dichloro-7-methylquinoline

7-methyl-1,2,3,4-tetrahydroquinoline

1-benzoyl-7-methyl-1,2,3,4-tetrahydro-quinoline

7-methyl-3-[2-(m-tolyl)hydrazono]quinoline-2,4-(1H,3H)-dione

Refernces

• 1、 Kappe, Thomas,Karem, Abdel S.,Stadlbauer, Wolfgang. "Synthesis of Benzo-halogenated 4-Hydroxy-2(1H)-quinolones". . p. 857 - 862. Retrieved 2007/10/02.