2-Amino-1-naphthol hydrochloride

Base Information

• Chemical Name: 2-Amino-1-naphthol hydrochloride
• CAS No.: 41772-23-0
• Molecular Formula: C10H9 N O . Cl H
• Molecular Weight: 195.648
• Hs Code.: 2922299090
• European Community (EC) Number: 255-548-5
• UNII: 0F1K0BRO5V
• DSSTox Substance ID: DTXSID90885848
• NSC Number: 97230
• Wikidata: Q27236693
• Mol file: 41772-23-0.mol

Synonyms:2-amino-1-naphthol;2-amino-1-naphthol hydrochloride

Chemical Property of 2-Amino-1-naphthol hydrochloride

Chemical Property:

• Vapor Pressure: 3.52E-05mmHg at 25°C
• Melting Point: 200-202 °C
• Boiling Point: 343.5°Cat760mmHg
• Flash Point: 161.6°C
• PSA: 46.25000
• Density: g/cm³
• LogP: 3.51080
• Solubility.: soluble in Methanol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 195.0450916
• Heavy Atom Count: 13
• Complexity: 160

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-1-naphthol Hydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38-40-41
• Safety Statements: 26-36/37/39-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC(=C2O)N.Cl

Technology Process of 2-Amino-1-naphthol hydrochloride

There total 2 articles about 2-Amino-1-naphthol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2-hydroxyimino-1,2,3,4-tetrahydronaphthalen-1-one (39262-02-7) → 1-hydroxy-2-naphthylamine hydrochloride (41772-23-0) + 2-amino-1,2,3,4-tetrahydronaphthalen-1-one hydrochloride (6298-95-9)

Guidance literature:

With hydrogenchloride; hydrogen; Pd-BaSO₄; In methanol; water; for 1.33333h; under 2585.7 Torr;

Reference yield:

3,4-dihydronaphthalene-1(2H)-one (529-34-0) → 1-hydroxy-2-naphthylamine hydrochloride (41772-23-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) t-BuOK, 2.) n-BuNO₂, 3.) 12 M HCl

2: H₂, 12 M HCl / Pd/BaSO₄ / methanol; H₂O / 1.33 h / 2585.7 Torr

With hydrogenchloride; 1-nitrobutane; potassium tert-butylate; hydrogen; Pd-BaSO₄; In methanol; water;

Reference yield: 60.0%

α,α-dibromo-p-toluic acid (29045-93-0) + 1-hydroxy-2-naphthylamine hydrochloride (41772-23-0) → 2-(4-Dibromomethyl-phenyl)-1-oxa-3-aza-cyclopenta[a]naphthalene (78659-78-6)

Guidance literature:

With polyphosphoric acid esters; at 120 - 140 ℃; for 0.75h;

DOI:10.1007/BF00503327

upstream raw materials:

2-hydroxyimino-1,2,3,4-tetrahydronaphthalen-1-one

3,4-dihydronaphthalene-1(2H)-one

Downstream raw materials:

2-(4-Dibromomethyl-phenyl)-1-oxa-3-aza-cyclopenta[a]naphthalene

2-diazo-1,2-naphthoquinone

Ethyl 3-((1-Hydroxy(2-naphthyl))amino)-2-((2,3,4,5-tetrafluorophenyl)carbonyl)prop-2-enoate

Refernces