Leptomycin A

Base Information

• Chemical Name: Leptomycin A
• CAS No.: 87081-36-5
• Molecular Formula: C32H46 O6
• Molecular Weight: 526.7
• Hs Code.: 3822000000
• NSC Number: 369326
• Nikkaji Number: J2.842.317I
• Mol file: 87081-36-5.mol

Synonyms:leptomycin A

Chemical Property of Leptomycin A

Chemical Property:

• Vapor Pressure: 8.56E-24mmHg at 25°C
• Boiling Point: 717.7°C at 760 mmHg
• Flash Point: 224.2°C
• PSA: 100.90000
• Density: 1.079g/cm³
• LogP: 6.39460
• Storage Temp.: ?20°C
• XLogP3: 7.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 14
• Exact Mass: 526.32943918
• Heavy Atom Count: 38
• Complexity: 1010

Purity/Quality:

95-99% ^*data from raw suppliers

Leptomycin A ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,T
• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 16-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1C=CC(=O)OC1C=CC(=CC(C)CC=CC(=CC(C)C(=O)C(C)C(C(C)CC(=CC(=O)O)C)O)C)C
• Isomeric SMILES: CC1C=CC(=O)OC1/C=C/C(=C/C(C)C/C=C/C(=C/C(C)C(=O)C(C)C(C(C)C/C(=C/C(=O)O)/C)O)/C)/C
• Description: Leptomycin A is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A inhibits Rev translocation, though less potently than leptomycin B with IC50 values of 0.8 and 0.1 nM, respectively after 7 hours. Rev export to the cytoplasm is required for HIV-1 replication. Leptomycin A was originally identified as an antifungal agent.
• Uses: Leptomycin A is an antifungal antibiotic. Leptomycin A, a methyl analogue of leptomycin B, is a minor component of the leptomycin complex produced by selected Streptomyces species. Leptomycin B is a potent inhibitor of the nuclear transport receptor CRM1. Leptomycin A is also likely to inhibit nuclear transport and may offer differences in exporter selectivity. Leptomycin A shows antimicrobial activity against Schizosaccaromyces pombe and Mucor rouxianus.