2-(4-(2-amino-2-oxoethoxy)-1-benzyl-2-ethyl-1H-indol-3-yl)-2-oxoacetamide

Base Information

• Chemical Name: 2-(4-(2-amino-2-oxoethoxy)-1-benzyl-2-ethyl-1H-indol-3-yl)-2-oxoacetamide
• CAS No.: 185298-58-2
• Molecular Formula: C21H21N3O4
• Molecular Weight: 379.41
• Mol file: 185298-58-2.mol

Synonyms:

Chemical Property of 2-(4-(2-amino-2-oxoethoxy)-1-benzyl-2-ethyl-1H-indol-3-yl)-2-oxoacetamide

Chemical Property:

• Melting Point: >230 °C
• Boiling Point: 709.0±70.0 °C(Predicted)
• PKA: 12.65±0.50(Predicted)
• Density: 1.32±0.1 g/cm3(Predicted)

Purity/Quality:

99%+, ^*data from raw suppliers

MDK-8582（Hnps-PLAInhibitor） >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(2-amino-2-oxoethoxy)-1-benzyl-2-ethyl-1H-indol-3-yl)-2-oxoacetamide

There total 6 articles about 2-(4-(2-amino-2-oxoethoxy)-1-benzyl-2-ethyl-1H-indol-3-yl)-2-oxoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1-Benzyl-4-carbamoylmethoxy-2-ethyl-1H-indol-3-yl)-oxo-acetyl chloride → 2-(1-Benzyl-4-carbamoylmethoxy-2-ethyl-1H-indol-3-yl)-2-oxo-acetamide (185298-58-2)

Guidance literature:

With ammonia; In dichloromethane;

DOI:10.1021/jm960487f

Reference yield:

1-benzyl-2-ethyl-1H-indol-4-ol (172733-06-1) → 2-(1-Benzyl-4-carbamoylmethoxy-2-ethyl-1H-indol-3-yl)-2-oxo-acetamide (185298-58-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) NaH / 1.) DMF, 40 min, 2.) DMF, 17 h

2: 70 percent / hydrazine / ethanol / 1 h / Heating

3: 69 percent / Raney nickel / ethanol / 2 h / Heating

4: CH₂Cl₂ / 1.33 h

5: NH₃ / CH₂Cl₂

With ammonia; nickel; sodium hydride; hydrazine; In ethanol; dichloromethane;

DOI:10.1021/jm960487f

Reference yield:

2-(1-Benzyl-2-ethyl-1H-indol-4-yloxy)-acetamide (185298-46-8) → 2-(1-Benzyl-4-carbamoylmethoxy-2-ethyl-1H-indol-3-yl)-2-oxo-acetamide (185298-58-2)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 1.33 h

2: NH₃ / CH₂Cl₂

With ammonia; In dichloromethane;

DOI:10.1021/jm960487f

upstream raw materials:

1-benzyl-2-ethyl-1H-indol-4-ol

2-(1-Benzyl-2-ethyl-1H-indol-4-yloxy)-acetamide

2-[[2-Ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid methyl ester

(1-Benzyl-2-ethyl-1H-indol-4-yloxy)-acetic acid hydrazide

Refernces