1-benzylpyridin-2-one

Base Information

• Chemical Name: 1-benzylpyridin-2-one
• CAS No.: 1753-62-4
• Molecular Formula: C12H11NO
• Molecular Weight: 185.225
• Hs Code.: 2933399990
• Mol file: 1753-62-4.mol

Synonyms:1-(phenylmethyl)-1,2-dihydropyridine-2-one;N-benzyl-2-(1H)-pyridone;1-Benzyl-2(1H)-pyridone;N-benzylpyridin-2-one;1-benzyl-2(1H)-pyridinone;1-benzyl-2-pyridone;N-benzylpyridone;1-benzylpyridin-2(1H)-one;

Chemical Property of 1-benzylpyridin-2-one

Chemical Property:

• Vapor Pressure: 3E-06mmHg at 25°C
• Boiling Point: 388.7°Cat760mmHg
• Flash Point: 190.9°C
• PSA: 22.00000
• Density: 1.165g/cm³
• LogP: 1.89660

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-benzyl-1,2-dihydropyridin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-benzylpyridin-2-one

There total 40 articles about 1-benzylpyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-fluoropyridine (372-48-5) + benzyl phenyl sulfoxide (7417-81-4,20246-02-0,73610-10-3,210539-77-8,833-82-9) → N-benzyl-2-pyridone (1753-62-4)

Guidance literature:

2-fluoropyridine; benzyl phenyl sulfoxide; With trifluoromethylsulfonic anhydride; In dichloromethane; at -43 - 20 ℃; for 10h; Schlenk technique;

With water; sodium hydrogencarbonate; at 20 ℃; for 0.166667h;

DOI:10.1039/c8ob00860d

Reference yield: 96.0%

2-Pyridone (142-08-5,1199357-22-6) + benzyl bromide (100-39-0) → N-benzyl-2-pyridone (1753-62-4)

Guidance literature:

With potassium carbonate; In 1,2-dimethoxyethane; at 70 ℃; for 16h; Inert atmosphere;

DOI:10.1002/asia.201900865

Reference yield: 95.0%

2-hydroxypyridin (142-08-5) + benzyl alcohol (100-51-6,185532-71-2) → N-benzyl-2-pyridone (1753-62-4)

Guidance literature:

With benzyl bromide; at 130 ℃; for 24h; Green chemistry;

upstream raw materials:

2-aminopyridine

benzoic acid benzyl ester

2-benzyloxypyridine

N-benzylpyridinium chloride

Downstream raw materials:

6-benzyl-8-endo-methoxycarbonyl-7-oxo-6-azabicyclo<3.2.1>oct-2-ene-2-carboxylic acid

2-benzyl-2-aza-bicyclo[2.2.0]hex-5-en-3-one

(1α,2α,6α,7α)-8-benzyl-8-azatricyclo<5.4.0.0^2,6>undeca-3,10-dien-9-one

(1α,2α,5α,6α)-7-benzyl-7-azatricyclo<4.2.2.1^2,5>undeca-3,9-dien-8-one

Refernces

• 1、 Changtong, Chuchawin,Carney, Daniel W.,Luo, Lan,Zoto, Christopher A.,Lombardi, John L.,Connors, Robert E.. "A porphyrin molecule that generates, traps, stores, and releases singlet oxygen". . p. 9 - 13. Retrieved 2013.
• 2、 Passarella, Daniele,Favia, Raffaele,Giardini, Alessandra,Lesma, Giordano,Martinelli, Marisa,Silvani, Alessandra,Danieli, Bruno,Efange, Simon M. N.,Mash, Deborah C.. "Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes". . p. 1007 - 1014. Retrieved 2003.
• 3、 Chen, Peiling,Carroll, Patrick J.,Sieburth, Scott McN.. "Intramolecular reactivity of trans [4+4] photodimers of 2-pyridones". . p. 2351 - 2359. Retrieved 2007.
• 4、 Tao, Shanqing,Xiao, Jiaxi,Li, Yadong,Sun, Fengxia,Du, Yunfei. "PhICl2/NH4SCN-Mediated Oxidative Regioselective Thiocyanation of Pyridin-2(1H)-ones". . p. 2536 - 2546. Retrieved 2021/07/31.
• 5、 Zhou, Min-Jie,Zhang, Lei,Liu, Guixia,Xu, Chen,Huang, Zheng. "Site-Selective Acceptorless Dehydrogenation of Aliphatics Enabled by Organophotoredox/Cobalt Dual Catalysis". supporting information. p. 16470 - 16485. Retrieved 2021/10/20.