2'-chloroetoposide

Base Information

• Chemical Name: 2'-chloroetoposide
• CAS No.: 138261-30-0
• Molecular Formula: C29H31 Cl O13
• Molecular Weight: 623.01
• Mol file: 138261-30-0.mol

Synonyms:Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one,5-(2-chloro-4-hydroxy-3,5-dimethoxyphenyl)-9-[(4,6-O-ethylidene-b-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-,[5S-[5a,5ab,8aa,9b(S*)]]-;Pyrano[3,2-d]-1,3-dioxin, furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-onederiv.

Chemical Property of 2'-chloroetoposide

Chemical Property:

• Boiling Point: 798.1°Cat760mmHg
• Flash Point: 436.5°C
• PSA: 160.83000
• Density: 1.6g/cm³
• LogP: 1.99200

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2'-chloroetoposide

There total 1 articles about 2'-chloroetoposide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

etoposide (33419-42-0) → 2'-chloroetoposide (138261-30-0)

Guidance literature:

With N-chloro-succinimide; In N,N-dimethyl-formamide; for 3.5h; Ambient temperature;

DOI:10.1021/jm00083a009

upstream raw materials:

etoposide

Refernces

• 1、 Hu,Wang,Liu,Cheng,Lee. "Antitumor agents. 123. Synthesis and human DNA topoisomerase II inhibitory activity of 2'-chloro derivatives of etoposide and 4β-(arylamino)-4'-O- demethylpodophyllotoxins". . p. 866 - 871. Retrieved 2007/10/02.