3-Oxazolidineethanol

Base Information

• Chemical Name: 3-Oxazolidineethanol
• CAS No.: 20073-50-1
• Deprecated CAS: 126208-22-8
• Molecular Formula: C5H11 N O2
• Molecular Weight: 117.148
• Hs Code.: 2934999090
• European Community (EC) Number: 243-499-2
• DSSTox Substance ID: DTXSID8066553
• Nikkaji Number: J280.435B
• Wikidata: Q81993129
• Mol file: 20073-50-1.mol

Synonyms:3-Oxazolidineethanol;20073-50-1;2-(3-Oxazolidine)ethanol;2-(oxazolidin-3-yl)ethanol;2-(1,3-oxazolidin-3-yl)ethanol;n-(2-hydroxyethyl)oxazolidine;2-(1,3-Oxazolidin-3-Yl)Ethan-1-Ol;EINECS 243-499-2;oxazolidine-3-ethanol;SCHEMBL308185;DTXSID8066553;2-(1,3-oxazolidin-3-yl)-ethanol;MFCD00043560;n-(2-hydroxyethyl)-1,3-oxazolidine;AKOS006272341;BS-51296;CS-0374348;FT-0629146;2-(1,3-Oxazolidin-3-yl)ethanol, AldrichCPR;E78021;EN300-216139;3-AMINO-4-METHOXYBENZENE-METHANAMINEDIHYDROCHLORIDE

Chemical Property of 3-Oxazolidineethanol

Chemical Property:

• Vapor Pressure: 0.0549mmHg at 25°C
• Boiling Point: 206.8°Cat760mmHg
• Flash Point: 78.8°C
• PSA: 32.70000
• Density: 1.106g/cm³
• LogP: -0.79370
• Water Solubility.: 1000g/L at 25℃
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 117.078978594
• Heavy Atom Count: 8
• Complexity: 67.4

Purity/Quality:

99.9% ^*data from raw suppliers

2-(3-Oxazolidine)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCN1CCO

Technology Process of 3-Oxazolidineethanol

There total 5 articles about 3-Oxazolidineethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2,2'-iminobis[ethanol] (111-42-2) → 2-(oxazolidin-3-yl)ethanol (20073-50-1)

Guidance literature:

In isopropyl alcohol; toluene; for 18h; Heating;

DOI:10.1016/0040-4020(96)00222-0

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2,2'-iminobis[ethanol] (111-42-2) + isovaleraldehyde (590-86-3) → 2-(oxazolidin-3-yl)ethanol (20073-50-1) + N-(2-hydroxyethyl)-2-isopropyloxazolidine (28770-01-6) + 2,2-dimethyl-3-hydroxypropionaldehyde (597-31-9) + 3-(N,N-bis(2-hydroxyethyl)amino)-2,2-dimethylpropanal (1122612-55-8)

Guidance literature:

In water; at 80 ℃; for 2h; Inert atmosphere; Cooling;

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2,2'-iminobis[ethanol] (111-42-2) + butan-1-ol (71-36-3) → 2-(oxazolidin-3-yl)ethanol (20073-50-1)

Guidance literature:

at 50 ℃;

upstream raw materials:

formaldehyd

2,2'-iminobis[ethanol]

butan-1-ol

isovaleraldehyde

Downstream raw materials:

2-(bis(2-hydroxyethyl)amino)acetonitrile

N-Methyldiethanolamine

1-benzoyloxy-2-oxazolidin-3-yl-ethane

2-<(bis-2-hydroxyethyl)aminomethyl>-3,5-dimethoxy-6-formylphenol

Refernces

• 1、 Gandhi, Tejas S.,Patel, Mayank R.,Dholakiya, Bharatkumar Z.. "Synthesis and characterization of different types of epoxide-based Mannich polyols from low-cost cashew nut shell liquid". . p. 1223 - 1232. Retrieved 2014/05/06.
• 2、 Farzaliev,Abbasova,Gamidova,Kerimova,Babaeva,Safarova. "Synthesis and antimicrobial properties of 3-(β-hydroxyethyl)-1,3- oxazolidins". scheme or table. p. 81 - 84. Retrieved 2012/06/30.