Boc-Cys(Trt)-OH DCHA

Base Information

• Chemical Name: Boc-Cys(Trt)-OH DCHA
• CAS No.: 26988-59-0
• Molecular Formula: C27H29NO4S.C12H23N
• Molecular Weight: 644.90600
• Mol file: 26988-59-0.mol

Synonyms:Dicyclohexylamine (R)-2-((tert-butoxycarbonyl)amino)-3-(tritylthio)propanoate;

Chemical Property of Boc-Cys(Trt)-OH DCHA

Chemical Property:

• PSA: 116.45000
• LogP: 9.52630
• Storage Temp.: 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

Boc-Cys(Trt)-OH.DCHA 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Boc-Cys(Trt)-OH DCHA

There total 2 articles about Boc-Cys(Trt)-OH DCHA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyldicarbonate (34619-03-9) + S-trityl-L-cysteine (2799-07-7) + N-cyclohexyl-cyclohexanamine (101-83-7) + citric acid (77-92-9,906507-37-7) → N-Boc-S-trityl-L-cysteine dicyclohexylamine salt (26988-59-0)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane;

Reference yield:

S-trityl-L-cysteine (2799-07-7) + 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile (58632-95-4) + N-cyclohexyl-cyclohexanamine (101-83-7) → N-Boc-S-trityl-L-cysteine dicyclohexylamine salt (26988-59-0)

Guidance literature:

In dichloromethane; for 24h; Ambient temperature;

DOI:10.1139/v88-425

Reference yield:

N-Boc-S-trityl-L-cysteine dicyclohexylamine salt (26988-59-0) → phenceptin (118002-46-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 10 percent citric acid; 2.) EEDQ / 1.) ethyl acetate, 10 percent citric acid; 2.) ethyl acetate, EEDQ, 10 min; 3.) ethyl acetate, 20 h

2: 65 percent / I₂ / methanol; CH₂Cl₂; pyridine / 2 h

With iodine; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; citric acid; In pyridine; methanol; dichloromethane;

DOI:10.1139/v88-425

upstream raw materials:

S-trityl-L-cysteine

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

N-cyclohexyl-cyclohexanamine

tert-butyldicarbonate

Downstream raw materials:

N-Boc-S-trityl-L-cysteinyl-glycyl-L-prolyl-glycyl-L-prolyl-S-trityl-L-cysteine benzhydryl ester

phenceptin

Refernces

• 1、 -. "Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents". . . Retrieved 2008/06/13.