2-Chloromalonaldehyde

Base Information

• Chemical Name: 2-Chloromalonaldehyde
• CAS No.: 36437-19-1
• Molecular Formula: C3H3ClO2
• Molecular Weight: 106.509
• Hs Code.: 29130000
• Mol file: 36437-19-1.mol

Synonyms:Malonaldehyde,chloro- (6CI);Propanedial, chloro- (9CI);2-Chloro-1,3-propanedial;Chloromalonaldehyde;Chloromalonic dialdehyde;

Chemical Property of 2-Chloromalonaldehyde

Chemical Property:

• Vapor Pressure: 22.8mmHg at 25°C
• Melting Point: 140-145 °C
• Refractive Index: 1.414
• Boiling Point: 204.6 °C at 760 mmHg
• PKA: 1.48±0.10(Predicted)
• Flash Point: 77.5 °C
• PSA: 34.14000
• Density: 1.371 g/cm³
• LogP: -0.00840
• Storage Temp.: 0-6°C
• Solubility.: DMSO (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

2-Chloromalonaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 36/37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Chloromalonaldehyde is used in the synthesis of novel heterocyclic acetyl coenzyme-A carboxylase inhibitors. Also used in the production of aldose reductase inhibitors used in the treatment of diabetes mellitus.

Technology Process of 2-Chloromalonaldehyde

There total 10 articles about 2-Chloromalonaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

→ 2-chloromalonaldehyde (36437-19-1)

Guidance literature:

Reference yield:

1,2,3,3-tetrachloro-1-propene (20589-85-9) → 2-chloromalonaldehyde (36437-19-1)

Guidance literature:

With sulfuric acid;

Reference yield:

5-tert-butoxy-6-chloro-2,3-dihydro-5H-[1,4]dioxepine (65041-41-0) → 2-chloromalonaldehyde (36437-19-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; Ambient temperature;

upstream raw materials:

malondialdehyde bis(diethyl acetal)

1,2,3,3-tetrachloro-1-propene

5-tert-butoxy-6-chloro-2,3-dihydro-5H-[1,4]dioxepine

7,7-dichloro-2,5-dioxybicyclo <4.1.0> heptane

Downstream raw materials:

2-methylthiazole-4-carboxyaldehyde

2-(4-chloro-phenyl)-thiazole-5-carbaldehyde

2-(4-bromo-2-methyl-phenyl)-thiazole-5-carbaldehyde

2-chloro-5-(4-chloro-1H-pyrazol-1-yl)pyridine

Refernces

• 1、 -. "Method of treating cancer". . . Retrieved 2008/06/13.
• 2、 -. "Substituted pyridines as selective cyclooxygenase-2 inhibitors". . . Retrieved 2008/06/13.