2-cyclohexylisoindole-1,3-dione

Base Information

• Chemical Name: 2-cyclohexylisoindole-1,3-dione
• CAS No.: 2133-65-5
• Molecular Formula: C14H15NO2
• Molecular Weight: 229.279
• Hs Code.: 2925190090
• Mol file: 2133-65-5.mol

Synonyms:N-Cyclohexylphthalimide;Phthalimide, N-cyclohexyl-;1H-Isoindole-1,3 (2H)-dione, 2-cyclohexyl-;

Chemical Property of 2-cyclohexylisoindole-1,3-dione

Chemical Property:

• Vapor Pressure: 2.69E-05mmHg at 25°C
• Refractive Index: 1.61
• Boiling Point: 357.6°Cat760mmHg
• Flash Point: 156.2°C
• PSA: 37.38000
• Density: 1.254g/cm³
• LogP: 2.55320

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2-cyclohexylisoindole-1,3-dione

There total 68 articles about 2-cyclohexylisoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

carbon monoxide (201230-82-2) + o-iodo-methyl-benzoic acid (610-97-9) + cyclohexylamine (108-91-8,157973-60-9) → N-cyclohexylphthalimide (2133-65-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 1h; under 760.051 Torr; Schlenk technique;

DOI:10.1016/j.apcata.2018.04.043

Reference yield: 100.0%

phthalimide (136918-14-4,85-41-6) + cyclohexylamine (108-91-8,157973-60-9) → N-cyclohexylphthalimide (2133-65-5)

Guidance literature:

With Iron(III) nitrate nonahydrate; In toluene; for 20h; Reflux;

DOI:10.1021/jo500562w

Reference yield: 97.0%

phthalic anhydride (85-44-9) + cyclohexylamine (108-91-8,157973-60-9) → N-cyclohexylphthalimide (2133-65-5) + N-cyclohexylphthalamic acid (19357-06-3)

Guidance literature:

phthalic anhydride; cyclohexylamine; In N,N-dimethyl acetamide; at 20 ℃; for 24h;

In N,N-dimethyl acetamide; xylene; at 140 ℃; for 48h;

DOI:10.1021/ma049232z

upstream raw materials:

phthalic anhydride

cyclohexylamine

2-(2-bromoethyl)isoindoline-1,3-dione

2-cyclohexyl-isoindoline

Downstream raw materials:

N-Cyclohexyl-N'-propyl-phthalamide

N,N'-dicyclohexyldiamide of phthalic acid

(±)-2-cyclohexyl-3-hydroxy-1-isoindolinone

1,2-trans-bromocyclohexylphthalimide

Refernces

• 1、 Basari?, Nikola,Mandi?, Leo,Sohora, Margareta. "[3 + 2] Cycloaddition with photogenerated azomethine ylides in β-cyclodextrin". . p. 1296 - 1304. Retrieved 2020.
• 2、 Mali, Anil S.,Indalkar, Krishna,Chaturbhuj, Ganesh U.. "Solvent-free, Efficient Transamidation of Carboxamides with Amines Catalyzed by Recyclable Sulfated Polyborate Catalyst". . p. 369 - 378. Retrieved 2021/07/26.