2-Pyridinethiol 1-oxide

Base Information

• Chemical Name: 2-Pyridinethiol 1-oxide
• CAS No.: 1121-31-9
• Molecular Formula: C5H5NOS
• Molecular Weight: 127.167
• Hs Code.: 29333990
• Mol file: 1121-31-9.mol

Synonyms:Pyridine-2-thiol N-oxide;BRN 0906983;2-Mercaptopyridine monoxide;

Chemical Property of 2-Pyridinethiol 1-oxide

Chemical Property:

• Appearance/Colour: off-white powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 70-73 °C
• Refractive Index: 1.614
• Boiling Point: 253.8 °C at 760 mmHg
• PKA: 5.40±0.50(Predicted)
• Flash Point: 107.3 °C
• PSA: 64.26000
• Density: 1.43 g/cm³
• LogP: 1.40380
• Storage Temp.: Refrigerator
• Sensitive.: Air & Light Sensitive
• Solubility.: Soluble in tris-hydrochloric acid.

Purity/Quality:

99% ^*data from raw suppliers

2-Mercaptopyridine N-oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22-63-20/21/22
• Safety Statements: 26-36-24/25-36/37-22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Mercaptopyridine N-oxide is used in ratiometric fluorescence imaging of intracellular zinc ions in mammalian cultures. It is used in the radical coupling of benzoyl derivatives of 2-deoxy-D-ribose, with heterocyclic bases to give C-nucleosides. It acts as a ligand and form coordination complexes with palladium chloride. It is a precursor to O-acyl thiohydroxamates. Further, it serves as an antifungal agent. In addition to this, it is used in the preparation of 1-oxa-2-oxo-3-thia-indolizinium chloride by reaction with carbonyl dichloride. Precursor to O-acyl thiohydroxamates. Ligates to metals to form biologically active complexes.

Technology Process of 2-Pyridinethiol 1-oxide

There total 5 articles about 2-Pyridinethiol 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-chloropyridine-N-oxide (2402-95-1) → 2-mercaptopyridine N-oxide (1121-31-9)

Guidance literature:

With sodium sulfide; sodium hydrogensulfide; In water; at 95 ℃; for 0.5h;

DOI:10.1081/SCC-120027260

Reference yield:

propan-1-ol (71-23-8) + 2-chloropyridine N-oxide hydrochloride (20295-64-1) → 2-mercaptopyridine N-oxide (1121-31-9)

Guidance literature:

With sodium carbonate; thiourea; In water;

Reference yield:

(2-((((6R)-2-carboxy-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]-oct-2-en-3-yl)methyl)thio)pyridine 1-oxide) → 2-mercaptopyridine N-oxide (1121-31-9)

Guidance literature:

With New Delhi metallo-β-lactamase 1; In aq. buffer; at 37 ℃; pH=7.2;

DOI:10.1021/acsinfecdis.0c00083

upstream raw materials:

2-chloropyridine-N-oxide

2-chloropyridine

propan-1-ol

2-chloropyridine N-oxide hydrochloride

Downstream raw materials:

2-Sulfanylpyridine

Refernces

• 1、 -. "Synthesis method of zinc pyrithione". Paragraph 0033; 0034; 0035; 0036; 0037; 0038; 0039; 0040. . Retrieved 2018/04/02.
• 2、 -. "Antivesicant compounds and methods of making and using thereof". . . Retrieved 2008/06/13.