Bis(2-Methoxyethyl)amine

Base Information

• Chemical Name: Bis(2-Methoxyethyl)amine
• CAS No.: 111-95-5
• Molecular Formula: C6H15NO2
• Molecular Weight: 133.191
• Hs Code.: H15NO2 MOL WT. 133.19
• European Community (EC) Number: 203-923-9
• NSC Number: 78431
• DSSTox Substance ID: DTXSID4059411
• Nikkaji Number: J193.599B
• Wikidata: Q72490209
• Mol file: 111-95-5.mol

Synonyms:dimethoxyethylamine

Chemical Property of Bis(2-Methoxyethyl)amine

Chemical Property:

• Appearance/Colour: Colorless to yellow liquid
• Vapor Pressure: 1.43mmHg at 25°C
• Melting Point: < -60 °C
• Refractive Index: n20/D 1.419(lit.)
• Boiling Point: 171 °C at 760 mmHg
• PKA: 8.67±0.19(Predicted)
• Flash Point: 58.3 °C
• PSA: 30.49000
• Density: 0.893 g/cm³
• LogP: 0.25970
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility.: Completely miscible in water
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 133.110278721
• Heavy Atom Count: 9
• Complexity: 44.3

Purity/Quality:

98%,99%, ^*data from raw suppliers

Bis(2-methoxyethyl)amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCNCCOC

Technology Process of Bis(2-Methoxyethyl)amine

There total 12 articles about Bis(2-Methoxyethyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

bis(2-methoxyethyl)(triphenylsilyl)amine → Bis-(2-methoxyethyl)amine (111-95-5)

Guidance literature:

With naphthalene; lithium; In tetrahydrofuran; methanol; at 20 ℃; for 5h;

DOI:10.1016/j.tet.2005.03.145

Reference yield: 90.0%

N,N-bis(2-methoxyethyl)tritylamine → Bis-(2-methoxyethyl)amine (111-95-5)

Guidance literature:

N,N-bis(2-methoxyethyl)tritylamine; With naphthalene; lithium; In tetrahydrofuran; at 0 ℃; for 2h;

With water; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1055/s-2004-822358

Reference yield: 90.0%

→ 2-cyanoethyl N,N-bis(2-methoxyethyl)-3-aminopropionate (449165-79-1) + Bis-(2-methoxyethyl)amine (111-95-5)

Guidance literature:

upstream raw materials:

2-chloroethyl methyl ether

2-methoxyethylamine

2-methoxy-ethanol

2-Bromoethyl methyl ether

Downstream raw materials:

N³,N³-Bis-(2-methoxy-ethyl)-2,4-dinitro-6-trifluoromethyl-benzene-1,3-diamine

N,N-bis(2-methoxy-ethyl)-hydroxylamine

Benzoic acid [bis-(2-methoxy-ethyl)-carbamoyl]-methyl ester

1-<<methyl>dimethylsilyl>-2-(4-methyl-3-cyclohexenyl)-2-propene

Refernces

• 1、 -. "METHOD FOR DEPROTECTING ARYL OR ALKYL SULFONAMIDES OF PRIMARY OR SECONDARY AMINES". Page/Page column 7. . Retrieved 2009/12/24.
• 2、 Behloul, Cherif,Guijarro, David,Yus, Miguel. "Deacylation of esters, thioesters and amides by a naphthalene-catalysed lithiation". . p. 309 - 314. Retrieved 2007/10/03.